Cell Surface Engineering: Fabrication of Functional Nanoshells
CHAPTER 11: Cell Surface Engineering Using a Layer-by-Layer Nanofilm for Biomedical Applications
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Published:08 Jul 2014
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Michiya Matsusaki, Mitsuru Akashi, 2014. "Cell Surface Engineering Using a Layer-by-Layer Nanofilm for Biomedical Applications", Cell Surface Engineering: Fabrication of Functional Nanoshells, Rawil Fakhrullin, Insung Choi, Yuri Lvov
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Nearly all tissue cells in the body reside in the micrometer-sized fibrous meshwork of the extracellular matrix (ECM). The ECM is typically composed of fibronectin (FN), collagen and laminin, and provides complex biochemical and physical signals.1–3 The ECM not only acts as storage for growth factors and cytokines but also induces cell–cell contacts and cell–matrix interactions.4 Accordingly, control of the cellular microenvironment using artificial ECM and growth factors will be important in vitro technique to control cell growth, cytokine expression, stem-cell differentiation, and cellular assembly. To control cellular microenvironment, the patterning of substrate surfaces5 and the chemical...