Cell Surface Engineering: Fabrication of Functional Nanoshells
CHAPTER 4: Bioinspired Encapsulation of Living Cells within Inorganic Nanoshells
Published:08 Jul 2014
Ji Hun Park, Juno Lee, Beom Jin Kim, Sung Ho Yang, 2014. "Bioinspired Encapsulation of Living Cells within Inorganic Nanoshells", Cell Surface Engineering: Fabrication of Functional Nanoshells, Rawil Fakhrullin, Insung Choi, Yuri Lvov
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For a decade, individual living cells have been encased within polyelectrolytes and nanomaterials.1,2 Layer-by-layer (LbL) self-assembly is the deposition or assembly of polyelectrolytes/nanomaterials, applied sequentially to the surfaces of living cells, through electrostatic interactions between oppositely charged polyelectrolytes or nanomaterials. LbL films are useful in integrating living cells with various materials for the following reasons.3 (1) LbL films are formed in a substrate-nonspecific manner, but are only manipulated by the surface charge. (2) Their thickness can be finely controlled on a 1-nm scale by the number of depositions. (3) LbL films are fabricated with extremely simple and low-cost processes, which make them highly accessible. (4) All the processes involved can be performed in biorelevant conditions, such as aqueous media, ambient pressure, and room temperature.