Hazardous Reagent Substitution: A Pharmaceutical Perspective
Chapter 3: Recoverable Polymer-supported DMAP Derivatives
Published:28 Nov 2017
Christopher E. Hobbs, 2017. "Recoverable Polymer-supported DMAP Derivatives", Hazardous Reagent Substitution: A Pharmaceutical Perspective, Rakesh Kumar Sharma, Rakeshwar Bandichhor
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The development of methods aimed at the replacement of potentially dangerous and toxic chemical reagents is a very important endeavor in modern organic chemistry. The inspiration of this is rooted in the emergence of “Green Chemistry”.1 Anastas described this philosophy as 12 operating principles that describe the importance of waste generation, using non-toxic and environmentally benign reagents, atom economy, and catalysis. These principles have been implemented into every branch of chemical sciences and have led to incredible advances in the way that chemists (especially synthetic chemists) create new compounds and materials.
Often, synthetic chemists are interested in utilizing the...