Metal Chelation in Medicine
Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning.
Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.
Metal Chelation in Medicine, The Royal Society of Chemistry, 2016.
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Table of contents
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CHAPTER 1: Metal Toxicity – An Introductionp1-23ByRobert R. CrichtonRobert R. CrichtonSearch for other works by this author on:
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CHAPTER 2: Basic Principles of Metal Chelation and Chelator Designp24-55ByYongmin MaYongmin MaZhejiang Chinese Medical UniversityHangzhouChinaSearch for other works by this author on:
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CHAPTER 3: Chelation Therapy For Heavy Metalsp56-105ByPeter NielsenPeter NielsenInstitute of Biochemistry and Molecular Cell Biology, Centre of Experimental medicine, University medical Centre Hamburg-Eppendorf20246 HamburgGermanynielsen@uke.deSearch for other works by this author on:
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CHAPTER 4: Treatment of Systemic Iron Overloadp106-152ByJohn PorterJohn PorterSearch for other works by this author on:
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CHAPTER 5: Treatment of Neurodegenerative Diseases by Chelatorsp153-182ByRobert R. CrichtonRobert R. CrichtonSearch for other works by this author on:
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CHAPTER 6: Chelation of Actinidesp183-212ByRebecca J. AbergelRebecca J. AbergelChemical Sciences Division, Lawrence Berkeley National LaboratoryOne Cyclotron RoadBerkeleyCA 94720USArjabergel@lbl.govSearch for other works by this author on:
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CHAPTER 7: Evaluation of Iron Overload by Non-Invasive Measurement Techniquesp213-259ByRoland FischerRoland FischerUniversity Medical Centre Hamburg-Eppendorf, Department of Pediatric Hematology/OncologyD-20246 HamburgGermanyUCSF Benioff Children's Hospital and Research Center Oakland, Department of Hematology/OncologyOaklandCA 94609USAfischer@uke.uni-hamburg.deSearch for other works by this author on:
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CHAPTER 8: Chelators for Diagnostic Molecular Imaging with Radioisotopes of Copper, Gallium and Zirconiump260-312ByMichelle T. Ma;Michelle T. MaKing’s College London, Division of Imaging Sciences and Biomedical Engineering4th Floor Lambeth Wing, St Thomas’ HospitalLondon SE1 7EHUKmichelle.ma@kcl.ac.ukSearch for other works by this author on:Philip J. BlowerPhilip J. BlowerKing’s College London, Division of Imaging Sciences and Biomedical Engineering4th Floor Lambeth Wing, St Thomas’ HospitalLondon SE1 7EHUKmichelle.ma@kcl.ac.ukSearch for other works by this author on:
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