Peroxynitrite Detection in Biological Media: Challenges and Advances
Peroxynitrite is a powerful oxidiser which can damage a wide array of molecules within cells, including DNA and proteins, leading to apoptosis, inflammation or cancer. Peroxynitrite detection and quantification provides critical information in understanding its biological implications. Attempts to investigate the behavior of peroxynitrite in vivo and in vitro have been hampered by the difficulty in detecting this highly reactive oxygen species. This book presents the current state of the art in this research field with contributions from scientific leaders in the field. The chapters make clear the associated challenges and development for selective and sensitive detection of peroxynitrite.
This book is a timely addition to the literature, as the first in the field, dedicated to detecting this molecule in vivo. It will be welcomed by the community particularly medicinal and analytical chemists, developers of sensors and probes and analytical equipment manufacturers.
Peroxynitrite Detection in Biological Media: Challenges and Advances, The Royal Society of Chemistry, 2015.
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CHAPTER 1: Peroxynitrite: The Basicsp1-11ByWillem H. KoppenolWillem H. KoppenolInstitute of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of TechnologyZürich 8093Switzerland[email protected]Search for other works by this author on:
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CHAPTER 2: Quantifying Peroxynitrite: Bridging the Gap Between Chemistry, Biology and Immunologyp12-47BySabine BorgmannSabine BorgmannResearch Department Interfacial Systems Chemistry (RD IFSC), Ruhr-Universität Bochum, Fakultät für Chemie und BiochemieNC 02/168, Universitätsstr. 15044801 BochumGermany[email protected]Search for other works by this author on:
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CHAPTER 3: Methods of Peroxynitrite Synthesis in the Context of the Development and Validation of Peroxynitrite Sensorsp48-62ByMekki Bayachou;Mekki BayachouDepartment of Chemistry, Cleveland State University2399 Euclid AveClevelandOhio 44115USA[email protected]Department of Pathobiology, Lerner Research Institute, The Cleveland ClinicClevelandOhio 44195USASearch for other works by this author on:Ghaith Altawallbeh;Ghaith AltawallbehDepartment of Chemistry, Cleveland State University2399 Euclid AveClevelandOhio 44115USA[email protected]Search for other works by this author on:Haitham Kalil;Haitham KalilDepartment of Chemistry, Cleveland State University2399 Euclid AveClevelandOhio 44115USA[email protected]Search for other works by this author on:Sarah Wojciechowski;Sarah WojciechowskiDepartment of Chemistry, Cleveland State University2399 Euclid AveClevelandOhio 44115USA[email protected]Search for other works by this author on:Tiyash BoseTiyash BoseDepartment of Chemistry, Cleveland State University2399 Euclid AveClevelandOhio 44115USA[email protected]Search for other works by this author on:
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CHAPTER 4: Peroxynitrite-Sensitive Electrochemically Active Matricesp63-77BySabine Szunerits;Sabine SzuneritsInstitut d’Electronique, de Microélectronique et de Nanotechnologie, CNRS UMR8520Avenue Poincaré – CS 6006959652 Villeneuve d’AscqFrance[email protected]Search for other works by this author on:Serban Peteu;Serban PeteuChemical Engineering and Materials Science, Michigan State University3523 Engineering BuildingEast LansingMichigan 48824United StatesSearch for other works by this author on:Rabah BoukherroubRabah BoukherroubInstitut d’Electronique, de Microélectronique et de Nanotechnologie, CNRS UMR8520Avenue Poincaré – CS 6006959652 Villeneuve d’AscqFrance[email protected]Search for other works by this author on:
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CHAPTER 5: Electrochemical Detection of Peroxynitrite in Biological Solutions: Challenges and Perspectivesp78-95BySophie Griveau;Sophie GriveauPSL Research University, Chimie ParisTech, Unité de Technologies Chimiques et Biologiques pour la SantéParisFrance[email protected]CNRS, Unité de Technologies Chimiques et Biologiques pour la Santé UMR 8258ParisFranceUniversité Paris Descartes, Unité de Technologies Chimiques et Biologiques pour la SantéParisFranceINSERM, Unité de Technologies Chimiques et Biologiques pour la Santé (N°1022)ParisFranceSearch for other works by this author on:Fethi BediouiFethi BediouiPSL Research University, Chimie ParisTech, Unité de Technologies Chimiques et Biologiques pour la SantéParisFrance[email protected]CNRS, Unité de Technologies Chimiques et Biologiques pour la Santé UMR 8258ParisFranceUniversité Paris Descartes, Unité de Technologies Chimiques et Biologiques pour la SantéParisFranceINSERM, Unité de Technologies Chimiques et Biologiques pour la Santé (N°1022)ParisFranceSearch for other works by this author on:
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CHAPTER 6: Real Time Monitoring of Peroxynitrite by Stimulation of Macrophages with Ultramicroelectrodesp96-120ByFrédéric LemaîtreFrédéric LemaîtreSearch for other works by this author on:
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CHAPTER 7: Electrophoretic Methods for Separation of Peroxynitrite and Related Compoundsp121-150ByJoseph M. Siegel;Joseph M. SiegelRalph N. Adams Institute for Bioanalytical Chemistry, University of KansasLawrenceKSUSASearch for other works by this author on:Richard P. S. de Campos;Richard P. S. de CamposRalph N. Adams Institute for Bioanalytical Chemistry, University of KansasLawrenceKSUSAChemistry Institute, State University of CampinasSPBrazilNational Institute of Science and Technology in Bioanalytics, INCTBioBrazilSearch for other works by this author on:Dulan B. Gunasekara;Dulan B. GunasekaraRalph N. Adams Institute for Bioanalytical Chemistry, University of KansasLawrenceKSUSADepartment of Chemistry, University of North CarolinaChapel HillNCUSASearch for other works by this author on:José A. F. da Silva;José A. F. da SilvaChemistry Institute, State University of CampinasSPBrazilNational Institute of Science and Technology in Bioanalytics, INCTBioBrazilSearch for other works by this author on:Susan M. LunteSusan M. LunteRalph N. Adams Institute for Bioanalytical Chemistry, University of KansasLawrenceKSUSASearch for other works by this author on:
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CHAPTER 8: Investigation of Peroxynitrite–Biomembrane Interactions Using Biomimetic Interfacesp151-165ByYing Liu;Ying LiuChemical Engineering and Materials Science, Michigan State UniversityEast LansingMI 48824USA[email protected]Search for other works by this author on:Serban F. Peteu;Serban F. PeteuChemical Engineering and Materials Science, Michigan State UniversityEast LansingMI 48824USA[email protected]Search for other works by this author on:R. Mark WordenR. Mark WordenChemical Engineering and Materials Science, Michigan State UniversityEast LansingMI 48824USA[email protected]Search for other works by this author on:
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CHAPTER 9: Recent Approaches to Enhance the Selectivity of Peroxynitrite Detectionp166-185ByAlina Vasilescu;Alina VasilescuInternational Centre of Biodynamics1 B Intrarea Portocalelor060101BucharestRomaniaSearch for other works by this author on:Valentina Dinca;Valentina DincaNational Institute for Laser, Plasma and Radiation Physics (INFLPR)Str Atomistilor 409, PO Box MG-36077125MagureleBucharestRomaniaSearch for other works by this author on:Mihaela Filipescu;Mihaela FilipescuNational Institute for Laser, Plasma and Radiation Physics (INFLPR)Str Atomistilor 409, PO Box MG-36077125MagureleBucharestRomaniaSearch for other works by this author on:Laurentiu Rusen;Laurentiu RusenNational Institute for Laser, Plasma and Radiation Physics (INFLPR)Str Atomistilor 409, PO Box MG-36077125MagureleBucharestRomaniaSearch for other works by this author on:Ioana S. Hosu;Ioana S. HosuNational Institute for R&D in Chemistry and Petrochemistry, ICECHIMSplaiul Independentei 202060021 BucharestRomaniaSearch for other works by this author on:Rabah Boukherroub;Rabah BoukherroubInstitut de Recherche Interdisciplinaire (IRI, USR 3078), Université Lille 1, Parc de la Haute Borne50 Avenue de Halley59658 Villeneuve d’AscqFranceSearch for other works by this author on:Sabine Szunerits;Sabine SzuneritsInstitut de Recherche Interdisciplinaire (IRI, USR 3078), Université Lille 1, Parc de la Haute Borne50 Avenue de Halley59658 Villeneuve d’AscqFranceSearch for other works by this author on:Maria Dinescu;Maria DinescuNational Institute for Laser, Plasma and Radiation Physics (INFLPR)Str Atomistilor 409, PO Box MG-36077125MagureleBucharestRomaniaSearch for other works by this author on:Serban F. PeteuSerban F. PeteuNational Institute for R&D in Chemistry and Petrochemistry, ICECHIMSplaiul Independentei 202060021 BucharestRomaniaChemical Engineering & Materials Science, Michigan State University3523, Engineering Building, 428 S. Shaw LnEast LansingMI 48824-1226USA[email protected][email protected]Search for other works by this author on:
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CHAPTER 10: Development of Fluorescent Probes for the Detection of Peroxynitritep186-207ByZhijie Chen;Zhijie ChenDepartment of Chemistry, University of California Riverside501 Big Springs RoadRiversideCA 92521USASearch for other works by this author on:Tan M. Truong;Tan M. TruongCell, Molecular and Developmental Biology Graduate Program, University of California RiversideRiversideCA 92521USA[email protected]Search for other works by this author on:Hui-wang AiHui-wang AiDepartment of Chemistry, University of California Riverside501 Big Springs RoadRiversideCA 92521USACell, Molecular and Developmental Biology Graduate Program, University of California RiversideRiversideCA 92521USA[email protected]Search for other works by this author on:
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CHAPTER 11: Reversible Near-Infrared Fluorescent Probes for Peroxynitrite Monitoringp208-226ByPeng Li;Peng LiState Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences457 Zhongshan RoadDalian 116023P. R. China[email protected]Search for other works by this author on:Keli HanKeli HanState Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences457 Zhongshan RoadDalian 116023P. R. China[email protected]Search for other works by this author on:
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