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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Publication date:
07 Oct 2016
Book Chapter
Chapter 10: Applications of the Comet Assay in Human Biomonitoring
By
Andrew R. Collins
;
Andrew R. Collins
Department of Nutrition, Faculty of Medicine, University of Oslo
Norway
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Maria Dusinska
Maria Dusinska
Norwegian Institute of Air Research (NILU)
Kjeller
Norway
Research Base of Slovak Medical University
Bratislava
Slovakia
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Page range:
238 - 263
Citation
A. R. Collins and M. Dusinska, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 10, pp. 238-263.
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This review will focus on biomarkers of genotoxic exposure and cancer risk, and in particular on the measurement of DNA damage and DNA repair using the Comet assay. Molecular biomarkers can be applied in the context of case-control, cohort or intervention studies. As in conventional epidemiology, study design and statistical considerations (especially power calculations) are critically important – as is the use of validated, reliable biomarker assays with sufficient sensitivity to detect individual differences with accuracy and precision.
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