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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Published online:
11 Oct 2016
Published in print:
07 Oct 2016
Book Chapter
Chapter 9: The Comet Assay: Clinical Applications
By
M. M. Piperakis
;
M. M. Piperakis
Department of Biological Chemistry, John Innes Centre, Norwich Research Park
Colney, Norwich
UK
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K. Kontogianni
;
K. Kontogianni
Department of Clinical Sciences, Liverpool School of Tropical Medicine
UK
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S. M. Piperakis
S. M. Piperakis
Biology Unit, Department of Pre-School Education, Faculty of Human Sciences, University of Thessaly
Volos
Greece
[email protected]
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Page range:
193 - 237
Citation
M. M. Piperakis, K. Kontogianni, and S. M. Piperakis, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 9, pp. 193-237.
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The single-cell gel electrophoresis (SCGE) or Comet assay is a technique widely employed in environmental and radiation toxicology as well as in cancer research with the aim of assessing DNA damage and repair by measuring DNA strand breaks. In the present review we outline the clinical applications of the Comet assay. In particular, we aim to highlight the importance of the technique in clinical medicine.
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