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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Publication date:
07 Oct 2016
Book Chapter
Chapter 18: Comet Assay – Protocols and Testing Strategies
By
Andreas Hartmann
;
Andreas Hartmann
Novartis Pharma AG, Preclinical Safety
WKL105.4. 09
CH-4002 Basel
Switzerland
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Günter Speit
Günter Speit
Universität Ulm, Institut für Humangenetik
D-89069 Ulm
Germany
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Citation
A. Hartmann and G. Speit, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 18, pp. 498-514.
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The assessment of a genotoxic hazard of chemicals and pharmaceuticals is an important component of the preclinical safety assessment. Experience with genetic toxicology testing over the past several decades has demonstrated that no single assay is capable of detecting all genotoxic effects. Therefore, the potential for a compound to cause genotoxicity is typically determined through a battery of in vitro and in vivo genotoxicity tests.
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