The Comet Assay in Toxicology
Chapter 14: The Alkaline Comet Assay in Prognostic Tests for Male Infertility and Assisted Reproductive Technology Outcomes
Published:07 Oct 2016
Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Sheena E. M. Lewis, Ishola M. Agbaje, 2016. "The Alkaline Comet Assay in Prognostic Tests for Male Infertility and Assisted Reproductive Technology Outcomes", The Comet Assay in Toxicology, Diana Anderson, Alok Dhawan
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In this review the relationship between actual sperm DNA damage as determined by the alkaline Comet assay and potential DNA damage as measured by DNA adduct testing will also be examined and the potential of routine clinical practices such as cryopreservation and prolonged incubation to induce further DNA damage investigated. The usefulness of sperm DNA tests as prognostic markers and in particular, the opportunities and challenges provided by DNA testing in male-fertility determination will be discussed.