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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Published online:
11 Oct 2016
Published in print:
07 Oct 2016
Book Chapter
Chapter 7: Detection of DNA Damage in Different Organs of the Mouse
By
Ritesh Kumar Shukla
;
Ritesh Kumar Shukla
Institute of Life Sciences, Ahmedabad University
University Road, Navrangpura
Ahmedabad – 380 009
India
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Mahima Bajpayee
;
Mahima Bajpayee
Shakti Sadan, 8, Arya Nagar
Lucknow – 226 004
India
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Alok Dhawan
Alok Dhawan
CSIR-Indian Institute of Toxicology Research
Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, P.O. Box No – 80
Lucknow – 226 001
India
[email protected]
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Page range:
164 - 176
Citation
R. K. Shukla, M. Bajpayee, and A. Dhawan, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 7, pp. 164-176.
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The in vivo mammalian alkaline Comet assay is used for assessing the DNA-damaging potential of chemicals in cells and tissues of rats and mice. The assay has been adopted by the OECD, as a second-tier test, in the standard battery of genotoxicity tests. This chapter outlines the protocol followed for performing the in vivo Comet assay in cells of blood and different organs e.g. liver, kidney, brain, spleen and bone marrow of mouse.
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