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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Publication date:
07 Oct 2016
Book Chapter
Chapter 16: Genotoxic Effects in Peripheral Blood and Sperm in Humans in Healthy Individuals and Those with Disease States
By
Diana Anderson
;
Diana Anderson
Department of Genetic and Reproductive Toxicology, School of Medical Sciences, Faculty of Life Sciences, University of Bradford
Richmond Road
Bradford, West Yorkshire
BD71DP
UK
[email protected]
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Adolf Baumgartner
;
Adolf Baumgartner
Department of Genetic and Reproductive Toxicology, School of Medical Sciences, Faculty of Life Sciences, University of Bradford
Richmond Road
Bradford, West Yorkshire
BD71DP
UK
[email protected]
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Mojgan Najafzadeh
Mojgan Najafzadeh
Department of Genetic and Reproductive Toxicology, School of Medical Sciences, Faculty of Life Sciences, University of Bradford
Richmond Road
Bradford, West Yorkshire
BD71DP
UK
[email protected]
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Page range:
457 - 476
Citation
D. Anderson, A. Baumgartner, and M. Najafzadeh, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 16, pp. 457-476.
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The comet assay is one of the most versatile tools in toxicology today and can be used to measure responses in both diploid (peripheral blood lymphocytes) and haploid (sperm) primary cells in humans. This chapter will discuss how these cells are employed to determine if they have differential responses to chemical and physical agents in healthy and disease-state individuals and how such information can be of use to man.
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