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Issues in Toxicology
The Comet Assay in Toxicology
Edited by
Alok Dhawan
Alok Dhawan
Centre of Biomedical Research, Lucknow, India
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Hardback ISBN:
978-1-78262-287-1
PDF ISBN:
978-1-78262-289-5
EPUB ISBN:
978-1-78262-915-3
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
Publication date:
07 Oct 2016
Book Chapter
Chapter 8: Detection of DNA Damage in Drosophila
By
Ashutosh Kumar
;
Ashutosh Kumar
Institute of Life Sciences, Ahmedabad University
University Road
Navrangpura
Ahmedabad – 380 009
India
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Mahima Bajpayee
;
Mahima Bajpayee
Shakti Sadan
8, Arya Nagar
Lucknow – 226 004
India
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Alok Dhawan
Alok Dhawan
CSIR-Indian Institute of Toxicology
Vishvigyan Bhavan
31-Mahatma Gandhi
MargP.O. Box – 80
Lucknow – 226 001
India
[email protected]
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Published:07 Oct 2016
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Special Collection: 2016 ebook collectionSeries: Issues in Toxicology
Page range:
177 - 192
Citation
A. Kumar, M. Bajpayee, and A. Dhawan, in The Comet Assay in Toxicology, ed. D. Anderson and A. Dhawan, The Royal Society of Chemistry, 2nd edn, 2016, ch. 8, pp. 177-192.
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Drosophila melanogaster has been extensively used as an alternative to animal models in genotoxicity testing. The alkaline Comet assay employing cells of Drosophila has been used as a simple and sensitive in vivo tool for the assessment of DNA damage and repair. It allows increased understanding of the mechanisms of genotoxicity and responses of biological systems to genotoxic chemicals that may be hazardous to humans. This chapter outlines the protocol followed for the in vivo alkaline comet assay using Drosophila.
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