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Metallobiology
2-Oxoglutarate-Dependent Oxygenases
Edited by
Christopher Schofield;
Christopher Schofield
University of Oxford, UK
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Robert Hausinger
Robert Hausinger
Michigan State University, USA
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Hardback ISBN:
978-1-84973-950-4
PDF ISBN:
978-1-78262-195-9
EPUB ISBN:
978-1-78262-500-1
No. of Pages:
487
Publication date:
23 Apr 2015
About this book
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia.
This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits.
The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
2-Oxoglutarate-Dependent Oxygenases, The Royal Society of Chemistry, 2015.
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2-Oxoglutarate-Dependent Oxygenases
$251.00
Table of contents
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CHAPTER 1: Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenasesp1-58ByRobert P. HausingerRobert P. HausingerDepartment of Microbiology and Molecular Genetics, Michigan State UniversityEast LansingMI 48824USADepartment of Biochemistry and Molecular Biology, Michigan State UniversityEast LansingMI 48824USA[email protected]Search for other works by this author on:
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CHAPTER 2: Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymesp59-94ByRadosław Nowak;Radosław NowakBotnar Research Centre, Oxford Biomedical Research UnitOxford OX3 7LDUKSearch for other works by this author on:Louise J. WalportLouise J. WalportSearch for other works by this author on:
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CHAPTER 3: Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyondp95-122ByJ. Martin Bollinger Jr.;J. Martin Bollinger Jr.Department of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Department of Biochemistry and Molecular Biology, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Search for other works by this author on:Wei-chen Chang;Wei-chen ChangDepartment of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Search for other works by this author on:Megan L. Matthews;Megan L. MatthewsDepartment of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Department of Chemical Physiology, The Scripps Research InstituteLa JollaCalifornia 92037USASearch for other works by this author on:Ryan J. Martinie;Ryan J. MartinieDepartment of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Search for other works by this author on:Amie K. Boal;Amie K. BoalDepartment of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Department of Biochemistry and Molecular Biology, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Search for other works by this author on:Carsten KrebsCarsten KrebsDepartment of Chemistry, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Department of Biochemistry and Molecular Biology, The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA[email protected]Search for other works by this author on:
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CHAPTER 4: Synthetic Models of 2-Oxoglutarate-Dependent Oxygenasesp123-148ByCaleb J. Allpress;Caleb J. AllpressDepartment of Chemistry and Center for Metals in Biocatalysis, University of MinnesotaMinneapolisMinnesota 55455USA[email protected]Search for other works by this author on:Scott T. Kleespies;Scott T. KleespiesDepartment of Chemistry and Center for Metals in Biocatalysis, University of MinnesotaMinneapolisMinnesota 55455USA[email protected]Search for other works by this author on:Lawrence Que JrLawrence Que JrDepartment of Chemistry and Center for Metals in Biocatalysis, University of MinnesotaMinneapolisMinnesota 55455USA[email protected]Search for other works by this author on:
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CHAPTER 5: Collagen Hydroxylasesp149-168ByJohanna MyllyharjuJohanna MyllyharjuOulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of OuluFinland[email protected]Search for other works by this author on:
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CHAPTER 6: The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensingp169-209ByChristopher J. SchofieldChristopher J. SchofieldSearch for other works by this author on:
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CHAPTER 7: JmjC Lysine Demethylasesp210-245ByXiaodong Cheng;Xiaodong ChengDepartment of Biochemistry, Emory UniversityAtlantaGA 30322USASearch for other works by this author on:Raymond C. TrievelRaymond C. TrievelSearch for other works by this author on:
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CHAPTER 8: AlkB and Its Homologues – DNA Repair and Beyondp246-262ByTina A. Müller;Tina A. MüllerDepartment of Microbiology and Molecular Genetics, Michigan State UniversityEast LansingMI 48824USASearch for other works by this author on:Robert P. HausingerRobert P. HausingerDepartment of Microbiology and Molecular Genetics, Michigan State UniversityEast LansingMI 48824USADepartment of Biochemistry and Molecular Biology, Michigan State UniversityEast LansingMI 48824USA[email protected]Search for other works by this author on:
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CHAPTER 9: RNA Demethylation by FTO and ALKBH5p263-274ByGuanqun Zheng;Guanqun ZhengDepartment of Chemistry, Institute for Biophysical Dynamics, University of Chicago929 East 57th StreetChicagoILUSA[email protected]Search for other works by this author on:Chuan HeChuan HeDepartment of Chemistry, Institute for Biophysical Dynamics, University of Chicago929 East 57th StreetChicagoILUSA[email protected]Search for other works by this author on:
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CHAPTER 10: Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNAp275-288ByAngela Yeuan Yen HoAngela Yeuan Yen HoSearch for other works by this author on:
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CHAPTER 11: The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenasesp289-308ByL. Aravind;L. AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthBethesdaMD 20894USA[email protected]Search for other works by this author on:Dapeng Zhang;Dapeng ZhangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthBethesdaMD 20894USA[email protected]Search for other works by this author on:Lakshminarayan M. IyerLakshminarayan M. IyerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthBethesdaMD 20894USA[email protected]Search for other works by this author on:
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CHAPTER 12: 2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-D-Glucopyranosyloxymethyluracil) Synthesisp309-323ByDavid Reynolds;David ReynoldsDepartment of Biochemistry and Molecular Biology, University of GeorgiaDavison Life Sciences Building, 120 Green StreetAthensGA 30602-7229USA[email protected]Search for other works by this author on:Laura Cliffe;Laura CliffeDepartment of Biochemistry and Molecular Biology, University of GeorgiaDavison Life Sciences Building, 120 Green StreetAthensGA 30602-7229USA[email protected]Search for other works by this author on:Robert SabatiniRobert SabatiniDepartment of Biochemistry and Molecular Biology, University of GeorgiaDavison Life Sciences Building, 120 Green StreetAthensGA 30602-7229USA[email protected]Search for other works by this author on:
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CHAPTER 13: Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylasesp324-337ByFrédéric M. Vaz;Frédéric M. VazLaboratory Genetic Metabolic Diseases, Departments of Paediatrics and Clinical Chemistry, Emma Children’s Hospital, Academic Medical Center1105 AZAmsterdamThe Netherlands[email protected]Search for other works by this author on:Naomi van VliesNaomi van VliesLaboratory Genetic Metabolic Diseases, Departments of Paediatrics and Clinical Chemistry, Emma Children’s Hospital, Academic Medical Center1105 AZAmsterdamThe Netherlands[email protected]Search for other works by this author on:
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CHAPTER 14: Phytanoyl-CoA Hydroxylase: A 2-Oxoglutarate-Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humansp338-349ByRonald J. A. Wanders;Ronald J. A. WandersLaboratory Genetic Metabolic Diseases, Departments of Paediatrics, Emma Children’s Hospital, and Clinical Chemistry, Academic Medical Center, University of AmsterdamMeibergdreef 91105 AZAmsterdamthe Netherlands[email protected]Search for other works by this author on:Sacha Ferdinandusse;Sacha FerdinandusseLaboratory Genetic Metabolic Diseases, Departments of Paediatrics, Emma Children’s Hospital, and Clinical Chemistry, Academic Medical Center, University of AmsterdamMeibergdreef 91105 AZAmsterdamthe Netherlands[email protected]Search for other works by this author on:Merel S. Ebberink;Merel S. EbberinkLaboratory Genetic Metabolic Diseases, Departments of Paediatrics, Emma Children’s Hospital, and Clinical Chemistry, Academic Medical Center, University of AmsterdamMeibergdreef 91105 AZAmsterdamthe Netherlands[email protected]Search for other works by this author on:Hans R. WaterhamHans R. WaterhamLaboratory Genetic Metabolic Diseases, Departments of Paediatrics, Emma Children’s Hospital, and Clinical Chemistry, Academic Medical Center, University of AmsterdamMeibergdreef 91105 AZAmsterdamthe Netherlands[email protected]Search for other works by this author on:
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CHAPTER 15: Role of 2-Oxoglutarate-Dependent Oxygenases in Flavonoid Metabolismp350-366ByStefan Martens;Stefan MartensDepartment of Food Quality and Nutrition Department, IASMA Research and Innovation Centre, Fondazione Edmund Mach (FEM)Via E. Mach 138010 San Michele all’Adige (TN)Italy[email protected]Search for other works by this author on:Ulrich MaternUlrich MaternInstitut für Pharmazeutische Biologie und Biotechnologie, FB Pharmazie, Philipps-Universität MarburgDeutschhausstrasse 17aD-35032 MarburgGermanySearch for other works by this author on:
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CHAPTER 16: Gibberellin Metabolismp367-384ByAndrew L. PhillipsAndrew L. PhillipsSearch for other works by this author on:
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CHAPTER 17: 2-Oxoglutarate-Dependent Oxygenases of Cephalosporin Synthesisp385-400ByInger Andersson;Inger AnderssonDepartment of Cell and Molecular Biology, Uppsala UniversityBox 596, S-751 24UppsalaSweden[email protected]Search for other works by this author on:Karin ValegårdKarin ValegårdDepartment of Cell and Molecular Biology, Uppsala UniversityBox 596, S-751 24UppsalaSweden[email protected]Search for other works by this author on:
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CHAPTER 18: Recent Advances in the Structural and Mechanistic Biology of Non-Haem Fe(ii), 2-Oxoglutarate and O2-Dependent Halogenasesp401-413ByJanet L. Smith;Janet L. SmithLife Sciences Institute University of Michigan210 Washtenaw AvenueAnn ArborMI 48109USA[email protected]Department of Biological Chemistry, University of Michigan210 Washtenaw AvenueAnn ArborMI 48109USASearch for other works by this author on:Dheeraj KhareDheeraj KhareLife Sciences Institute University of Michigan210 Washtenaw AvenueAnn ArborMI 48109USA[email protected]Search for other works by this author on:
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CHAPTER 19: Isopenicillin N Synthasep414-424ByPeter J. RutledgePeter J. RutledgeSearch for other works by this author on:
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CHAPTER 20: 1-Aminocyclopropane-1-Carboxylic Acid Oxidase1p425-437ByA. Jalila Simaan;A. Jalila SimaanAix Marseille Université, CNRS, Centrale MarseilleiSm2 UMR 7313, 13397MarseilleFrance[email protected]Search for other works by this author on:Marius RéglierMarius RéglierAix Marseille Université, CNRS, Centrale MarseilleiSm2 UMR 7313, 13397MarseilleFrance[email protected]Search for other works by this author on:
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CHAPTER 21: 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicinep438-457ByDhara D. Shah;Dhara D. ShahDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee3210 N. Cramer StMilwaukeeWI 53211-3209USA[email protected]Search for other works by this author on:Graham R. MoranGraham R. MoranDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee3210 N. Cramer StMilwaukeeWI 53211-3209USA[email protected]Search for other works by this author on:
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