2-Oxoglutarate-Dependent Oxygenases
CHAPTER 3: Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond
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Published:23 Apr 2015
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J. Martin Bollinger Jr., Wei-chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal, Carsten Krebs, 2015. "Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond", 2-Oxoglutarate-Dependent Oxygenases, Christopher Schofield, Robert Hausinger
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One of nature’s most potent and versatile strategies for transformation of unactivated carbon centres involves activation of O2 at an Fe(ii) cofactor to form an Fe(iv)-oxo (ferryl) intermediate that can either react as an electrophile or abstract a hydrogen atom (H˙) to initiate the installation of a diverse array of functional groups. A large and biologically important subset of enzymes that employ this strategy generate their key ferryl intermediates by coupling activation of O2 at non-haem Fe(ii) cofactors to the oxidative decarboxylation of 2-oxoglutarate (2OG) to succinate and CO2.1–3...