2-Oxoglutarate-Dependent Oxygenases
CHAPTER 4: Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases
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Published:23 Apr 2015
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Caleb J. Allpress, Scott T. Kleespies, Lawrence Que Jr, 2015. "Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases", 2-Oxoglutarate-Dependent Oxygenases, Christopher Schofield, Robert Hausinger
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The 2-oxoglutarate (2OG)-dependent oxidases and oxygenases represent the largest family of non-haem iron enzymes.1 They employ 2OG as a cosubstrate to carry out a variety of metabolic transformations, many of which involve the cleavage of a substrate C–H bond. A consensus mechanism has emerged for 2OG-dependent enzymes leading to the formation of an Fe(iv)O species2 that is capable of a wide array of substrate oxidations, including hydroxylation, halogenation, desaturation, electrophilic aromatic substitution and epoxidation.3 Mechanistic studies, particularly by the Bollinger/Krebs group (see Chapter 3),3 have led to the proposed catalytic cycle shown in Figure...