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Issues in Toxicology
Human Stem Cell Toxicology
Edited by
James L Sherley
James L Sherley
Asymmetrex, LLC, USA
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Hardback ISBN:
978-1-78262-421-9
PDF ISBN:
978-1-78262-678-7
EPUB ISBN:
978-1-78262-873-6
Special Collection:
2016 ebook collection
Series:
Issues in Toxicology
No. of Pages:
299
Publication date:
09 Aug 2016
About this book
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents.
Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors.
This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Human Stem Cell Toxicology, The Royal Society of Chemistry, 2016.
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Digital access
$237.00
Print format
Human Stem Cell Toxicology
$237.00
Table of contents
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Chapter 1: Addressing Challenges to Progress in Human Stem Cell Toxicology Concepts and Practicep1-8ByJames L. SherleyJames L. SherleySearch for other works by this author on:
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Chapter 2: Alternative Methods in Haematopoietic Stem Cell Toxicologyp9-30ByNavneet Kumar Yadav;Navneet Kumar YadavHematological Facility, Division of Toxicology, CSIR-Central Drug Research InstituteBS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173Lucknow226031India[email protected][email protected]Search for other works by this author on:Pooja Shukla;Pooja ShuklaHematological Facility, Division of Toxicology, CSIR-Central Drug Research InstituteBS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173Lucknow226031India[email protected][email protected]Search for other works by this author on:R. K. SinghR. K. SinghHematological Facility, Division of Toxicology, CSIR-Central Drug Research InstituteBS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173Lucknow226031India[email protected][email protected]Search for other works by this author on:
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Chapter 3: High-throughput Screening of Toxic Chemicals on Neural Stem Cellsp31-63ByKurt Farrell;Kurt FarrellDepartment of Chemical and Biomedical EngineeringCleveland State UniversityClevelandOhio 44115-2214USA[email protected][email protected]Search for other works by this author on:Pranav Joshi;Pranav JoshiDepartment of Chemical and Biomedical EngineeringCleveland State UniversityClevelandOhio 44115-2214USA[email protected][email protected]Search for other works by this author on:Alexander Roth;Alexander RothDepartment of Chemical and Biomedical EngineeringCleveland State UniversityClevelandOhio 44115-2214USA[email protected][email protected]Search for other works by this author on:Chandrasekhar Kothapalli;Chandrasekhar KothapalliDepartment of Chemical and Biomedical EngineeringCleveland State UniversityClevelandOhio 44115-2214USA[email protected][email protected]Search for other works by this author on:Moo-Yeal LeeMoo-Yeal LeeDepartment of Chemical and Biomedical EngineeringCleveland State UniversityClevelandOhio 44115-2214USA[email protected][email protected]Search for other works by this author on:
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Chapter 4: The Role of Catecholamines in Stem Cell Mobilisationp64-93ByBríd M. Ryan;Bríd M. RyanLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer InstituteBethesdaMD 20892USA[email protected]Search for other works by this author on:Oscar VidalOscar VidalLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer InstituteBethesdaMD 20892USA[email protected]Search for other works by this author on:
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Chapter 5: Toxicological Risk Assessment – Proposed Assay Platform Using Stem and Progenitor Cell Differentiation in Response to Environmental Toxicantsp94-123ByJohn W. Ludlow;John W. LudlowZen Bio Inc.PO Box 138883200 E Hwy 54Suite 100Research Triangle ParkNorth Carolina 27709-3888USASearch for other works by this author on:Michael VanKanegan;Michael VanKaneganZen Bio Inc.PO Box 138883200 E Hwy 54Suite 100Research Triangle ParkNorth Carolina 27709-3888USASearch for other works by this author on:Ben Buehrer;Ben BuehrerZen Bio Inc.PO Box 138883200 E Hwy 54Suite 100Research Triangle ParkNorth Carolina 27709-3888USASearch for other works by this author on:Nick Trotta;Nick TrottaZen Bio Inc.PO Box 138883200 E Hwy 54Suite 100Research Triangle ParkNorth Carolina 27709-3888USASearch for other works by this author on:Joydeep BasuJoydeep BasuZen Bio Inc.PO Box 138883200 E Hwy 54Suite 100Research Triangle ParkNorth Carolina 27709-3888USASearch for other works by this author on:
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Chapter 6: Current Developments in the Use of Human Stem Cell Derived Cardiomyocytes to Examine Drug-induced Cardiotoxicityp124-159ByVarun Ahuja;Varun AhujaDrug Safety Assessment, Novel Drug Discovery and DevelopmentLupin Limited (Research Park), 46A/47ANande Village, Taluka-MulshiPune 412 115IndiaSearch for other works by this author on:Sharad Sharma;Sharad SharmaDrug Safety Assessment, Novel Drug Discovery and DevelopmentLupin Limited (Research Park), 46A/47ANande Village, Taluka-MulshiPune 412 115IndiaSearch for other works by this author on:Raj KambojRaj KambojNovel Drug Discovery and DevelopmentLupin Limited (Research Park)46A/47ANande VillageTaluka-MulshiPune 412 115India[email protected]Search for other works by this author on:
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Chapter 7: Pesticides and Hematopoietic Stem Cellsp160-177BySujata Law;Sujata LawStem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical MedicineKolkataWest BengalIndia[email protected]Search for other works by this author on:Malay ChakladerMalay ChakladerStem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical MedicineKolkataWest BengalIndia[email protected]Search for other works by this author on:
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Chapter 8: Epigenetic Impact of Stem Cell Toxicantsp178-195ByAnup Kumar Singh;Anup Kumar SinghBiochemistry Division, CSIR-Central Drug Research InstituteSector 10Jankipuram ExtensionLucknow226031India[email protected]Search for other works by this author on:Akhilesh Singh;Akhilesh SinghBiochemistry Division, CSIR-Central Drug Research InstituteSector 10Jankipuram ExtensionLucknow226031India[email protected]Search for other works by this author on:Rakesh Kumar Arya;Rakesh Kumar AryaBiochemistry Division, CSIR-Central Drug Research InstituteSector 10Jankipuram ExtensionLucknow226031India[email protected]Search for other works by this author on:Navneet Kumar Yadav;Navneet Kumar YadavToxicology Division, CSIR-Central Drug Research InstituteSector 10Jankipuram ExtensionLucknow226031IndiaSearch for other works by this author on:Dipak DattaDipak DattaBiochemistry Division, CSIR-Central Drug Research InstituteSector 10Jankipuram ExtensionLucknow226031India[email protected]Search for other works by this author on:
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Chapter 9: Metakaryotic Cancer Stem Cells are Constitutively Resistant to X-Rays and Chemotherapeutic Agents, but Sensitive to Many Common Drugsp196-249ByElena V. Gostjeva;Elena V. GostjevaLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:Vera V. Koledova;Vera V. KoledovaLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:Liyuan Bai;Liyuan BaiLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:Kailin C. Duan;Kailin C. DuanLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:Tushar Kamath;Tushar KamathLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:Parul Agnihotri;Parul AgnihotriDepartment of Pathology and Laboratory Medicine, Boston University Medical CampusBostonMAUSASearch for other works by this author on:Deborah J. Moshinski;Deborah J. MoshinskiCell Assay Innovations, Inc.BeverlyMAUSASearch for other works by this author on:Li Ping Wu;Li Ping WuCell Assay Innovations, Inc.BeverlyMAUSASearch for other works by this author on:Lawrence Zukerberg;Lawrence ZukerbergDepartment of Pathology, Massachusetts General HospitalBostonMAUSASearch for other works by this author on:Daniel C. Chung;Daniel C. ChungGastrointestinal Unit, Massachusetts General HospitalBostonMAUSASearch for other works by this author on:Susan Tsai;Susan TsaiDivision of Surgical Oncology, Medical College of WisconsinMilwaukeeWisconsinUSASearch for other works by this author on:Douglas B. Evans;Douglas B. EvansDepartment of Surgery, Medical College of WisconsinMilwaukeeWIUSASearch for other works by this author on:Aoy Tomita-Mitchell;Aoy Tomita-MitchellDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of WisconsinMilwaukeeWIUSASearch for other works by this author on:Michael Mitchell;Michael MitchellDivision of Cardiothoracic Surgery in the Department of Surgery, Children's Hospital of WisconsinMilwaukeeWIUSA[email protected]Search for other works by this author on:William G. ThillyWilliam G. ThillyLaboratory in Metakaryotic Biology, Department of Biological Engineering, Massachusetts Institute of TechnologyCambridgeMAUSASearch for other works by this author on:
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Chapter 10: Distributed Stem Cell Kinetotoxicity: A New Concept to Account for the Human Carcinogenicity of Non-genotoxic Environmental Toxicantsp250-279ByKrishnanchali Panchalingam;Krishnanchali PanchalingamSurface OncologyCambridgeMassachusettsUSASearch for other works by this author on:Minsoo Noh;Minsoo NohCollege of Pharmacy, Seoul National UniversitySeoulRepublic of KoreaSearch for other works by this author on:Yang Hoon Huh;Yang Hoon HuhNano-Bio EM Research Group, Korea Basic Science InstituteChungcheongguk-doRepublic of KoreaSearch for other works by this author on:James L. SherleyJames L. SherleySearch for other works by this author on:
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Chapter 11: Cancer Stem Cells as Therapeutic Targetsp280-294ByShinji TanakaShinji TanakaDepartment of Molecular Oncology, Tokyo Medical and Dental UniversityYushima 1-5-45Bunkyo-kuTokyo 113-8519Japan[email protected]Search for other works by this author on:
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