Human Stem Cell Toxicology
Chapter 2: Alternative Methods in Haematopoietic Stem Cell Toxicology
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Published:09 Aug 2016
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Special Collection: 2016 ebook collection
Navneet Kumar Yadav, Pooja Shukla, R. K. Singh, 2016. "Alternative Methods in Haematopoietic Stem Cell Toxicology", Human Stem Cell Toxicology, James L Sherley
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Hematopoietic stem cells are very primitive cells localized in the bone marrow (BM). They are pluripotent cells, having capacity for self-renewal and differentiation to produce all kinds of blood cells (e.g. T cells, B cells, natural killer cells, granulocytes, monocytes, erythrocytes and platelets) to perform different functional roles in the human body.1,2 The mature blood cells have a limited lifespan (several days to many years); thus, hematopoietic stem cells produce a large number of bloods cell every day to replace the dying cells and ultimately sustain the hematopoietic system of individuals throughout their lives (Figure 2.1)....