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Human Stem Cell Toxicology

Issues in Toxicology

Series Editors:

Professor Diana Anderson, University of Bradford, UK

Dr Michael D. Waters, Michael Waters Consulting, N. Carolina, USA

Dr Timothy C. Marrs, Edentox Associates, Kent, UK

Advisor to the Board:

Professor Alok Dhawan, CSIR-Indian Institute of Toxicology Research, Lucknow, India

Titles in the Series:

1: Hair in Toxicology: An Important Bio-Monitor

2: Male-mediated Developmental Toxicity

3: Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics

4: Bile Acids: Toxicology and Bioactivity

5: The Comet Assay in Toxicology

6: Silver in Healthcare

7: In Silico Toxicology: Principles and Applications

8: Environmental Cardiology

9: Biomarkers and Human Biomonitoring, Volume 1: Ongoing Programs and Exposures

10: Biomarkers and Human Biomonitoring, Volume 2: Selected Biomarkers of Current Interest

11: Hormone-Disruptive Chemical Contaminants in Food

12: Mammalian Toxicology of Insecticides

13: The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens

14: Toxicological Effects of Veterinary Medicinal Products in Humans: Volume 1

15: Toxicological Effects of Veterinary Medicinal Products in Humans: Volume 2

16: Aging and Vulnerability to Environmental Chemicals: Age-related Disorders and their Origins in Environmental Exposures

17: Chemical Toxicity Prediction: Category Formation and Read-Across

18: The Carcinogenicity of Metals: Human Risk Through Occupational and Environmental Exposure

19: Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

20: Advances in Dermatological Sciences

21: Metabolic Profiling: Disease and Xenobiotics

22: Manganese in Health and Disease

23: Toxicology, Survival and Health Hazards of Combustion Products

24: Masked Mycotoxins in Food: Formation, Occurrence and Toxicological Relevance

25: Aerobiology: The Toxicology of Airborne Pathogens and Toxins

26: Chemical Warfare Toxicology, Volume 1: Fundamental Aspects

27: Chemical Warfare Toxicology, Volume 2: Management of Poisoning

28: Toxicogenomics in Predictive Carcinogenicity

29: Human Stem Cell Toxicology

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK

Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247

Visit our website at

Human Stem Cell Toxicology

Edited by

James L. Sherley

Asymmetrex, LLC, Boston, MA, USA



Issues in Toxicology No. 29

Print ISBN: 978-1-78262-421-9

PDF eISBN: 978-1-78262-678-7

EPUB eISBN: 978-1-78262-873-6

ISSN: 1757-7179

A catalogue record for this book is available from the British Library

© The Royal Society of Chemistry 2016

All rights reserved

Apart from fair dealing for the purposes of research for non-commercial purposes or for private study, criticism or review, as permitted under the Copyright, Designs and Patents Act 1988 and the Copyright and Related Rights Regulations 2003, this publication may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry or the copyright owner, or in the case of reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page.

The RSC is not responsible for individual opinions expressed in this work.

The authors have sought to locate owners of all reproduced material not in their own possession and trust that no copyrights have been inadvertently infringed.

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Cambridge CB4 0WF, UK

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