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Green Chemistry Series
Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Edited by
James H Clark
James H Clark
University of York, UK
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Hardback ISBN:
978-1-78262-467-7
PDF ISBN:
978-1-78262-594-0
EPUB ISBN:
978-1-78262-747-0
Series:
Green Chemistry
No. of Pages:
272
Publication date:
08 Mar 2016
About this book
Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such as rapidly depleting resources, high energy costs and new legislation. This book addresses current challenges in modern green chemical technologies and sustainability thinking. It encompasses a broad range of topics covered by the CHEM21 project – Europe’s largest public-private partnership project which aims to develop a toolbox of sustainable technologies for green chemical intermediate manufacture. Divided into two sections, the book first gives an overview of the key green chemistry tools, guidance and considerations aimed at developing greener processes, before moving on to look at cutting-edge synthetic methodologies. Featuring innovative research, this book is an invaluable reference for chemists across academia and industry wanting to further their knowledge and understanding of this important topic.
Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016.
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Digital access
$209.00
Print format
Green and Sustainable Medicinal Chemistry
$209.00
Table of contents
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Chapter 1: Green and Sustainable Chemistry: An Introductionp1-11ByJames H. ClarkJames H. ClarkGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:
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Foreword: An Introduction to CHEM21 Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industriesp7-18ByMurray J. B. BrownMurray J. B. BrownSearch for other works by this author on:
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Chapter 2: Tools for Facilitating More Sustainable Medicinal Chemistryp12-27ByH. F. SneddonH. F. SneddonGSK, Medicines Research Centre, Green ChemistryGunnels Wood RoadStevenageHertsSG1 2NYUK[email protected]Search for other works by this author on:
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Chapter 3: Renewable Solvent Selection in Medicinal Chemistryp28-40ByJames H. Clark;James H. ClarkGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:Andrew J. Hunt;Andrew J. HuntGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:Laurianne Moity;Laurianne MoityGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:James SherwoodJames SherwoodGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:
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Chapter 4: Beyond Mass-based Metrics: Evaluating the Greenness of Your Reactionp41-53ByLouise Summerton;Louise SummertonGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:Andri ConstandinouAndri ConstandinouGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:
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Chapter 5: The Importance of Elemental Sustainability and Critical Element Recovery for the Pharmaceutical Industryp54-62ByAndrew J. HuntAndrew J. HuntGreen Chemistry Centre of Excellence, Department of Chemistry, University of YorkYorkYO10 5DDUK[email protected]Search for other works by this author on:
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Chapter 6: Presence, Fate and Risks of Pharmaceuticals in the Environmentp63-72ByKlaus KümmererKlaus KümmererSustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of LüneburgGermany[email protected]Search for other works by this author on:
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Chapter 7: Benign by Designp73-81ByKlaus KümmererKlaus KümmererSustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of LüneburgGermany[email protected]Search for other works by this author on:
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Chapter 8: From Discovery to Manufacturing: Some Sustainability Challenges Presented by the Requirements of Medicine Developmentp82-100ByJohn HaylerJohn HaylerGlaxoSmithKline Medicines Research CentreGunnels Wood RoadStevenageHertfordshireSG1 2NYUK[email protected]Search for other works by this author on:
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Chapter 9: Medicinal Chemistry: How “Green” is Our Synthetic Tool Box?p101-115BySirpa RaskuSirpa RaskuSearch for other works by this author on:
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Chapter 10: Design of Experiments (DoE) for Greener Medicinal Chemistryp116-128ByJonathan D. MoseleyJonathan D. MoseleySearch for other works by this author on:
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Chapter 11: Pd-catalysed Cross-couplings for the Pharmaceutical Sector and a Move to Cutting-edge C–H Bond Functionalization: Is Palladium Simply Too Precious?p129-139ByIan J. S. FairlambIan J. S. FairlambSearch for other works by this author on:
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Chapter 12: The Growing Impact of Continuous Flow Methods on the Twelve Principles of Green Chemistryp140-155ByA. John Blacker;A. John BlackerInstitute of Process Research and Development, School of Chemistry and School of Chemical and Process Engineering, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:Jessica R. Breen;Jessica R. BreenInstitute of Process Research and Development, School of Chemistry and School of Chemical and Process Engineering, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:Richard A. Bourne;Richard A. BourneInstitute of Process Research and Development, School of Chemistry and School of Chemical and Process Engineering, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:Christopher A. HoneChristopher A. HoneInstitute of Process Research and Development, School of Chemistry and School of Chemical and Process Engineering, University of LeedsLeedsLS2 9JTUK[email protected]Search for other works by this author on:
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Chapter 13: Green Catalytic Direct Amide Bond Formationp156-164ByFarhana K. Ferdousi;Farhana K. FerdousiCentre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science LaboratoriesSouth RoadDurhamDH1 3LEUK[email protected]Search for other works by this author on:Andrew WhitingAndrew WhitingCentre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science LaboratoriesSouth RoadDurhamDH1 3LEUK[email protected]Search for other works by this author on:
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Chapter 14: Synthetic Biology for Organic Synthesesp165-179ByBirgit Wiltschi;Birgit Wiltschiacib – Austrian Centre of Industrial BiotechnologyPetersgasse 14A-8010 GrazAustriaSearch for other works by this author on:Anton GliederAnton Gliederacib – Austrian Centre of Industrial BiotechnologyPetersgasse 14A-8010 GrazAustriaInstitute of Molecular Biotechnology, NAWI Graz, Graz University of TechnologyPetersgasse 14A-8010 GrazAustria[email protected]Search for other works by this author on:
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Chapter 15: Biocatalysis for Medicinal Chemistryp180-191ByA. S. WellsA. S. WellsCharnwood Technical Consulting LtdParklandsNorthage CloseQuornLeicestershireLE12 8ATUK[email protected]Search for other works by this author on:
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Chapter 16: Base Metals in Catalysis: From Zero to Herop192-202ByJ. Maes;J. MaesUniversity of Antwerp, Department of ChemistryGroenenborgerlaan 1712020 AntwerpenBelgium[email protected]Search for other works by this author on:E. A. Mitchell;E. A. MitchellUniversity of Antwerp, Department of ChemistryGroenenborgerlaan 1712020 AntwerpenBelgium[email protected]Search for other works by this author on:B. U. W. MaesB. U. W. MaesUniversity of Antwerp, Department of ChemistryGroenenborgerlaan 1712020 AntwerpenBelgium[email protected]Search for other works by this author on:
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Chapter 17: ‘Green’ and Sustainable Halogenation Processesp203-217ByGraham PattisonGraham PattisonSearch for other works by this author on:
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