Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Chapter 17: ‘Green’ and Sustainable Halogenation Processes
Published:08 Mar 2016
Special Collection: 2016 ebook collection , ECCC Environmental eBooks 1968-2022Series: Green Chemistry
Graham Pattison, 2016. "‘Green’ and Sustainable Halogenation Processes", Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark
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Halogen atoms have proven both to be some of the most useful functionality available to medicinal chemists, both as handles for further derivatisation and diversification and also due to the beneficial properties they, particularly fluorine, can impart on drug candidates. However, many reagents for halogenation can be potentially dangerous, difficult to handle and can have negative environmental impacts. This short chapter highlights recent approaches to avoid such difficult halogenation reagents and replace them with safer, more sustainable alternatives.