Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Chapter 11: Pd-catalysed Cross-couplings for the Pharmaceutical Sector and a Move to Cutting-edge C–H Bond Functionalization: Is Palladium Simply Too Precious?
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Published:08 Mar 2016
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Series: Green Chemistry
Ian J. S. Fairlamb, 2016. "Pd-catalysed Cross-couplings for the Pharmaceutical Sector and a Move to Cutting-edge C–H Bond Functionalization: Is Palladium Simply Too Precious?", Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark
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The case is made for Pd being a critical metal catalyst for a variety of key pharmaceutical sector reactions. There is a need to make such processes more sustainable, e.g. through catalyst recycling, use of lower catalyst loadings and deployment in sustainable C–H activation reactions that avoid high molecular weight waste side-products. Understanding the role played by higher order Pd species (nanoparticles and clusters) is essential in the future. These and related aspects are discussed within this chapter.
