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Green Chemistry Series
Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Edited by
James H Clark
James H Clark
University of York, UK
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Hardback ISBN:
978-1-78262-467-7
PDF ISBN:
978-1-78262-594-0
EPUB ISBN:
978-1-78262-747-0
Series:
Green Chemistry
No. of Pages:
272
Publication date:
08 Mar 2016
Book Chapter
Chapter 10: Design of Experiments (DoE) for Greener Medicinal Chemistry
By
Jonathan D. Moseley
Jonathan D. Moseley
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Published:08 Mar 2016
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Series: Green Chemistry
Citation
Jonathan D. Moseley, 2016. "Design of Experiments (DoE) for Greener Medicinal Chemistry", Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark
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This chapter discusses the potential and benefits of the application of experimental design (DoE) in early discovery chemistry. By convincing the reader of this, it seeks to show how this can lead to greener medicinal chemistry. DoE is explained briefly, before practical considerations are discussed in more detail. Finally, a short case study is presented to illustrate the possible benefits.
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