Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Chapter 3: Renewable Solvent Selection in Medicinal Chemistry
Published:08 Mar 2016
Special Collection: 2016 ebook collection , ECCC Environmental eBooks 1968-2022Series: Green Chemistry
James H. Clark, Andrew J. Hunt, Laurianne Moity, James Sherwood, 2016. "Renewable Solvent Selection in Medicinal Chemistry", Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark
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This chapter serves to raise awareness within medicinal chemistry of the possibilities regarding substitution in favour of more benign solvents. Although bio-based solvents are not universally safe and non-toxic, by virtue of being renewable they diminish concerns about the use of finite oil and natural gas reserves. The tools available to help phase out solvents with undesirable environmental impacts are presented with an emphasis on solvent polarity as a means of identifying replacement solvents.