Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Chapter 2: Tools for Facilitating More Sustainable Medicinal Chemistry
Published:08 Mar 2016
Special Collection: 2016 ebook collection , ECCC Environmental eBooks 1968-2022Series: Green Chemistry
H. F. Sneddon, 2016. "Tools for Facilitating More Sustainable Medicinal Chemistry", Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark
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Many green chemistry approaches appropriate to drug development, such as detailed metrics or life cycle analysis on specific routes, may be too time-consuming to be used on a day-to day basis in medicinal chemistry, where multiple routes to multiple different compounds are being considered. Instead simple tools, designed to be quick and easy to use, can help guide medicinal chemists towards making more sustainable choices, with the goal of both minimizing any adverse environmental impact of drug discovery operations, and hopefully minimising major route changes on candidates passed on to development. In addition these tools also have the potential to promote engagement with other aspects of green chemistry and wider sustainability initiatives. Common tools include a variety of solvent selection guides (including specific guidance for chromatography), tools which can minimise reliance on non-preferred solvents such as the use of hydrophilic frits and ion exchange chromatography, general reagent guides and more detailed guidance on the substrate specificity of common reagent/solvent combinations for frequently used transformations.