Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Chapter 9: Medicinal Chemistry: How “Green” is Our Synthetic Tool Box?
Published:08 Mar 2016
J. Messinger, L. Otsomaa, and S. Rasku, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, ed. L. Summerton, H. F. Sneddon, L. C. Jones, and J. H. Clark, The Royal Society of Chemistry, 2016, ch. 9, pp. 101-115.
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Medicinal chemistry departments in pharmaceutical companies or research institutes are considered to be providers of new chemical entities for testing in biological systems on mg and g scales. Time, yields and flexibility of a reaction play a major role during the optimisation cycles. Current standards of synthetic tools and techniques are discussed under the viewpoint of environmental aspects.