Asymmetric Functionalization of C–H Bonds
Asymmetric C-H direct functionalization reactions are one of the most active and fascinating areas of research in organic chemistry due to their significance in the construction of molecular complexity without pre-activation, and the step economy and atom economy features in potential synthetic application. Distinguishing the reactivity among numerous C–H bonds in one single molecule represents one of the most challenging issues in organic synthesis and requires precise reaction design. As such, this field is now receiving increasing attention from researchers.
This book provides the first comprehensive review of this field, summarizing the origin, mechanism, scope and applications of the asymmetric C-H bond functionalization reaction. It covers organocatalytic reactions and transition-metal-catalyzed reactions, as well as asymmetric C-H functionalization reactions not described in other books.
Written by a leading expert in this field, the book is ideal for postgraduates and researchers working in organic synthesis, catalysis, and organometallic chemistry.
Asymmetric Functionalization of C–H Bonds, The Royal Society of Chemistry, 2015.
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Table of contents
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CHAPTER 1: Asymmetric C–H Bond Insertion Reactionsp1-66ByWen-Ting Wu;Wen-Ting WuState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Ze-Peng Yang;Ze-Peng YangState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 2: Asymmetric Cross-Dehydrogenative Coupling (CDC) Reactionsp67-91ByShou-Guo Wang;Shou-Guo WangState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 3: Asymmetric Oxidative Biaryl Coupling Reactionsp92-125ByChao Zheng;Chao ZhengState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 4: Asymmetric [1,5]-Hydride Transfer Reactionsp126-140ByXiao-Wei Liang;Xiao-Wei LiangState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Chao Zheng;Chao ZhengState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 5: Asymmetric Functionalization of C–H Bonds via a Transient Carbon–Metal (C–M) Speciesp141-213ByDe-Wei Gao;De-Wei GaoState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Jun Zheng;Jun ZhengState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Ke-Yin Ye;Ke-Yin YeState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Chao Zheng;Chao ZhengState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 6: Asymmetric Friedel–Crafts Alkylation Reactionsp214-282ByQiang Kang;Qiang KangKey Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences155 Yangqiao Road WestFuzhou 350002ChinaSearch for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 7: N-Heterocyclic Carbene-Catalyzed Asymmetric Functionalization of Aldehyde C–H Bondsp283-357ByYi Li;Yi LiDepartment of Chemistry, Fuzhou UniversityFuzhou 350108ChinaSearch for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 8: Asymmetric Hydroacylation Reactionsp358-383ByQing-Long Xu;Qing-Long XuJiangsu Key Laboratory of Drug Discovery for Metabolic Disease and Center of Drug Discovery, China Pharmaceutical University24 Tongjia XiangNanjing 210009ChinaSearch for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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CHAPTER 9: Asymmetric Hydrovinylation Reactionsp384-404ByQing-Long Xu;Qing-Long XuJiangsu Key Laboratory of Drug Discovery for Metabolic Disease and Center of Drug Discovery, China Pharmaceutical University24 Tongjia XiangNanjing 210009ChinaSearch for other works by this author on:Shu-Li YouShu-Li YouState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences345 Lingling LuShanghai 200032China[email protected]Search for other works by this author on:
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