Mechanochemistry is the conversion of mechanical energy into chemical potential. For almost 60 years, studies focused on how stress degrades materials, and little attention was given to its potential as a methodology to drive chemical reaction. Since Encina’s work in 1980, mechanochemistry started ascending as a new approach to develop productive chemistry, with potential applications in several fields of science. In this chapter, we describe how scientists have been able to draw on mechanical energy to drive different chemical processes, developing new chemical reactions, molecular force probes, latent catalysts, mechanoresponsive materials and more.