Theranostics and Image Guided Drug Delivery
CHAPTER 6: Liposomes for Hyperthermia Triggered Drug Release
Published:02 Jan 2018
Special Collection: 2018 ebook collectionSeries: Drug Discovery
W. J. M. Lokerse, B. Kneidl, A. Rysin, M. Petrini, and L. H. Lindner, in Theranostics and Image Guided Drug Delivery, ed. M. Thanou, The Royal Society of Chemistry, 2018, pp. 137-163.
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The use of thermosensitive liposomes (TSLs) for anticancer treatment that were first described in the seventies has gained an increasing amount of attention over the years. In recent decades, various TSL formulations have been designed and tested in many different ways, all having various advantages and disadvantages. We here give an overview on the parameters: (1) base lipids; (2) cholesterol; (3) surface modification; (4) release improvement; (5) encapsulated drugs; (6) active targeting and (7) testing procedures of this broad variety of TSLs. By these means, we aim to establish a broader understanding on how to adequately design a TSL and to test these in a reliable manner. Furthermore, we provide a critical view on the investigated aspects of TSL that were successful and unsuccessful and highlight which areas still require more follow up research.