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Drug Discovery
Antibiotic Drug Discovery: New Targets and Molecular Entities
Edited by
Steven M Firestine;
Steven M Firestine
Wayne State University, USA
Search for other works by this author on:
Troy Lister
Troy Lister
Spero Therapeutics, USA
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Hardback ISBN:
978-1-78262-424-0
PDF ISBN:
978-1-78262-987-0
EPUB ISBN:
978-1-78801-149-5
Special Collection:
2017 ebook collection
Series:
Drug Discovery
No. of Pages:
271
Publication date:
19 May 2017
About this book
Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community.
In addition to its attention on new targets, the book focusses on the medicinal chemistry and chemistry of the targets. Within this framework, chapters from leading researchers in academia and industry address findings in important areas such as biofilm production, narrow spectrum antibiotics and novel antibacterials from previously uncultured soil bacteria.
This book will be a useful resource for postgraduate students and researchers in medicinal chemistry wishing to understand the latest approaches to antibiotic drug discovery.
Antibiotic Drug Discovery: New Targets and Molecular Entities, The Royal Society of Chemistry, 2017.
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Digital access
$237.00
Print format
Antibiotic Drug Discovery
$237.00
Table of contents
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CHAPTER 1: Treatment of Clostridium difficile Infectionsp1-19ByChristopher Yip;Christopher YipDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas4505 Maryland Parkway, Campus Box 4003Las VegasNV 89154USA[email protected]Search for other works by this author on:Jacqueline Phan;Jacqueline PhanDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas4505 Maryland Parkway, Campus Box 4003Las VegasNV 89154USA[email protected]Search for other works by this author on:Ernesto Abel-SantosErnesto Abel-SantosDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas4505 Maryland Parkway, Campus Box 4003Las VegasNV 89154USA[email protected]Search for other works by this author on:
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CHAPTER 2: Targeting Purine Biosynthesis for Antibacterial Drug Designp20-42ByGyan Modi;Gyan ModiBrandeis University, Departments of Biology and Chemistry, MS 009415 South StWalthamMA 02453USA[email protected]Current address: Indian Institute of Technology, Banaras Hindu University, Department of PharmaceuticsRoom #23Varanasi-221005IndiaSearch for other works by this author on:Shibin Chacko;Shibin ChackoBrandeis University, Departments of Biology and Chemistry, MS 009415 South StWalthamMA 02453USA[email protected]Search for other works by this author on:Lizbeth HedstromLizbeth HedstromBrandeis University, Departments of Biology and Chemistry, MS 009415 South StWalthamMA 02453USA[email protected]Search for other works by this author on:
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CHAPTER 3: Inhibitors of Biofilm Productionp43-75ByRoberta J. Melander;Roberta J. MelanderDepartment of Chemistry, North Carolina State UniversityRaleighNC27695USASearch for other works by this author on:Christian MelanderChristian MelanderDepartment of Chemistry, North Carolina State UniversityRaleighNC27695USASearch for other works by this author on:
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CHAPTER 4: Narrow Spectrum Antibacterial Agentsp76-102ByLauren A. Spagnuolo;Lauren A. SpagnuoloDepartment of Chemistry and Institute for Chemical Biology and Drug Discovery, Stony Brook UniversityStony BrookNY 11794USASearch for other works by this author on:Peter J. Tonge;Peter J. TongeDepartment of Chemistry and Institute for Chemical Biology and Drug Discovery, Stony Brook UniversityStony BrookNY 11794USASearch for other works by this author on:Stewart L. FisherStewart L. FisherSearch for other works by this author on:
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CHAPTER 5: The LPS Transport Pathway: A New Target for the Development of Gram-Negative Antibioticsp103-126ByAlison M. Berezuk;Alison M. BerezukDepartment of Molecular and Cellular Biology, University of GuelphGuelphOntarioCanada[email protected]Search for other works by this author on:Cezar M. KhursigaraCezar M. KhursigaraDepartment of Molecular and Cellular Biology, University of GuelphGuelphOntarioCanada[email protected]Search for other works by this author on:
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CHAPTER 6: The Discovery of Teixobactinp127-140ByV. A. SteadmanV. A. SteadmanSearch for other works by this author on:
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Chapter 7: Emerging Targets in Anti-Tubercular Drug Designp141-203ByKeith D. Green;Keith D. GreenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky789 South Limestone StreetLexingtonKY40536-0596USA[email protected]Search for other works by this author on:Selina Y. L. Holbrook;Selina Y. L. HolbrookDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky789 South Limestone StreetLexingtonKY40536-0596USA[email protected]Search for other works by this author on:Huy X. Ngo;Huy X. NgoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky789 South Limestone StreetLexingtonKY40536-0596USA[email protected]Search for other works by this author on:Sylvie Garneau-TsodikovaSylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky789 South Limestone StreetLexingtonKY40536-0596USA[email protected]Search for other works by this author on:
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CHAPTER 8: Antibacterial Leads Targeting Isoprenoid Biosynthesisp204-255ByCarl J. BalibarCarl J. BalibarMerck Research Laboratories2015 Galloping Hill Road, K15-D409-12KenilworthNJ 07033USA[email protected]Search for other works by this author on:
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