CHAPTER 6: Biology and Synthesis of the Argyrins
Published:14 Dec 2017
L. Millbrodt and M. Kalesse, in Cyclic Peptides: From Bioorganic Synthesis to Applications, ed. J. Koehnke, J. Naismith, and W. A. van der Donk, The Royal Society of Chemistry, 2017, pp. 122-140.
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Argyrins A–F, isolated in 2002, are non-ribosomal cyclic peptides exhibiting a unique framework. Their remarkable bioactivity includes antibiotic, immunosuppressive and antitumor properties. The explanation of their properties can be found in the inhibition of bacterial elongation factor G and p27kip1 inhibition. Synthetic studies towards argyrins A–F have been investigated by four groups using different novel pathways of polypeptide chemistry in three convergent approaches and one linear solid-phase peptide synthesis.