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Issues in Toxicology
Computational Systems Pharmacology and Toxicology
Edited by
Rudy J Richardson;
Rudy J Richardson
University of Michigan, USA
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Dale E Johnson
Dale E Johnson
University of Michigan, USA
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Hardback ISBN:
978-1-78262-332-8
PDF ISBN:
978-1-78262-373-1
EPUB ISBN:
978-1-78801-120-4
Special Collection:
2017 ebook collection
Series:
Issues in Toxicology
No. of Pages:
332
Publication date:
01 Mar 2017
Book Chapter
CHAPTER 5: Linking Drug or Phytochemical Exposure to Toxicity
By
C. A. Rodríguez
;
C. A. Rodríguez
Adjunct Associate Professor of Pharmaceutical Sciences, The University of Michigan
Ann Arbor
MI
USA
carodrig@umich.eduAdjunct Professor of Pharmaceutics and Medicinal Chemistry, University of the Pacific
Stockton
CA
USA
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N. S. Teuscher
;
N. S. Teuscher
Vice President of Scientific Training and Director of Strategic Consulting
Certara, Princeton
NJ
USA
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J. A. Uchizono
J. A. Uchizono
Professor of Pharmaceutics and Medicinal Chemistry, Associate Provost of Research, and Interim Dean of Graduate Studies, University of the Pacific
Stockton
CA
USA
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Published:01 Mar 2017
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Special Collection: 2017 ebook collectionSeries: Issues in Toxicology
Citation
C. A. Rodríguez, N. S. Teuscher, and J. A. Uchizono, in Computational Systems Pharmacology and Toxicology, ed. R. J. Richardson and D. E. Johnson, The Royal Society of Chemistry, 2017, pp. 89-119.
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The general strategy to linking exposure to toxicity follows well-established pharmacokinetic and pharmacodynamic principles and practices. In addition to reviewing the basic science behind pharmacokinetic and pharmacodynamic modeling, this chapter attempts to acquaint the reader with current modeling strategies by means of literature examples. Lastly, the subject of drug–drug interactions (from both a pharmacokinetic and a pharmacodynamic perspective) and some modeling approaches are also discussed.
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