Skip Nav Destination
Issues in Toxicology
Computational Systems Pharmacology and Toxicology
Edited by
Rudy J Richardson;
Rudy J Richardson
University of Michigan, USA
Search for other works by this author on:
Dale E Johnson
Dale E Johnson
University of Michigan, USA
Search for other works by this author on:
Hardback ISBN:
978-1-78262-332-8
PDF ISBN:
978-1-78262-373-1
EPUB ISBN:
978-1-78801-120-4
Special Collection:
2017 ebook collection
Series:
Issues in Toxicology
No. of Pages:
332
Publication date:
01 Mar 2017
Book Chapter
CHAPTER 5: Linking Drug or Phytochemical Exposure to Toxicity
By
C. A. Rodríguez
;
C. A. Rodríguez
Adjunct Associate Professor of Pharmaceutical Sciences, The University of Michigan
Ann Arbor
MI
USA
carodrig@umich.eduAdjunct Professor of Pharmaceutics and Medicinal Chemistry, University of the Pacific
Stockton
CA
USA
Search for other works by this author on:
N. S. Teuscher
;
N. S. Teuscher
Vice President of Scientific Training and Director of Strategic Consulting
Certara, Princeton
NJ
USA
Search for other works by this author on:
J. A. Uchizono
J. A. Uchizono
Professor of Pharmaceutics and Medicinal Chemistry, Associate Provost of Research, and Interim Dean of Graduate Studies, University of the Pacific
Stockton
CA
USA
Search for other works by this author on:
-
Published:01 Mar 2017
-
Special Collection: 2017 ebook collectionSeries: Issues in Toxicology
Citation
C. A. Rodríguez, N. S. Teuscher, J. A. Uchizono, 2017. "Linking Drug or Phytochemical Exposure to Toxicity", Computational Systems Pharmacology and Toxicology, Rudy J Richardson, Dale E Johnson
Download citation file:
The general strategy to linking exposure to toxicity follows well-established pharmacokinetic and pharmacodynamic principles and practices. In addition to reviewing the basic science behind pharmacokinetic and pharmacodynamic modeling, this chapter attempts to acquaint the reader with current modeling strategies by means of literature examples. Lastly, the subject of drug–drug interactions (from both a pharmacokinetic and a pharmacodynamic perspective) and some modeling approaches are also discussed.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Digital access
$64.60
