Anti-aging Drugs: From Basic Research to Clinical Practice
CHAPTER 21: HDAC Inhibitors: A New Avenue in Anti-Aging Medicine
Published:18 Jan 2017
Gradual loss of physiological functions accompanied by decreasing fertility and increased risk of mortality with advancing age is recognized as age-related senescence, a process immanent to most living beings. Whether senescence may be prevented and/or postponed by certain approaches is a matter of utmost importance in today’s world. Recent advances in biogerontology and an increasing number of pharmacological and dietary interventions suggested to have the anti-aging and life-extending effects1,2 give hope that senescence may be effectively combated in the near future.
In recent years, epigenetic regulatory mechanisms have become increasingly appreciated as central to a variety of age-associated processes,...