Chapter 2: Considerations Related to Small-molecule Screening Collections

The screening of small-molecule libraries is a fundamental aspect of generating high quality probes and therapeutic lead compounds. Critical to this activity is the assembly of a high quality collection of compounds that will comprise the library. This chapter will address important topics related to the assembly and performance of compound screening collections. The information presented may be useful in informing the types of compounds to include in a library or help explain assay outcomes based on the identity of pre-assembled screening collections.