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Chemical Biology
High Throughput Screening Methods: Evolution and Refinement
Edited by
Nathan T Ross
Nathan T Ross
Novartis Institutes for Biomedical Research, USA
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Hardback ISBN:
978-1-78262-471-4
PDF ISBN:
978-1-78262-677-0
EPUB ISBN:
978-1-78262-979-5
Special Collection:
2016 ebook collection
Series:
Chemical Biology
No. of Pages:
396
Publication date:
05 Dec 2016
Book Chapter
Chapter 3: Combination Screening
By
John Moffat
;
John Moffat
Department of Biochemical and Cellular Pharmacology, Genentech Research & Early Development
South San Francisco
USA
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Mats Gustafsson
Mats Gustafsson
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Published:05 Dec 2016
-
Special Collection: 2016 ebook collectionSeries: Chemical Biology
Page range:
37 - 57
Citation
C. R. Andersson, J. Moffat, and M. Gustafsson, in High Throughput Screening Methods: Evolution and Refinement, ed. J. A. Bittker and N. T. Ross, The Royal Society of Chemistry, 2016, ch. 3, pp. 37-57.
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Multi-compound treatment has attracted increasing interest in recent years due to vast unexplored prospects for novel therapeutics. In this chapter, we discuss the experimental design and statistical analysis of compound synergy assays. In particular, we describe how acoustic dispensing enables flexible layouts of assay plates, which greatly simplifies the study of compound combinations, and discuss measures of synergy as well as statistical properties when resampling based statistics are employed.
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