Chemical Biology of Glycoproteins
Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions.
Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.
Chemical Biology of Glycoproteins, The Royal Society of Chemistry, 2017.
Download citation file:
Digital access
Print format
Table of contents
-
Introduction: General Aspects of the Chemical Biology of Glycoproteinsp1-19ByPatrick K. Chaffey;Patrick K. ChaffeyDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of ColoradoBoulderCO 80303USA[email protected]Search for other works by this author on:Xiaoyang Guan;Xiaoyang GuanDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of ColoradoBoulderCO 80303USA[email protected]Search for other works by this author on:Lai-Xi Wang;Lai-Xi WangDepartment of Chemistry and Biochemistry, University of MarylandCollege ParkMD 20742USASearch for other works by this author on:Zhongping TanZhongping TanDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of ColoradoBoulderCO 80303USA[email protected]Search for other works by this author on:
-
CHAPTER 2: Chemical Biology of Protein N-Glycosylationp20-47ByChao Li;Chao LiDepartment of Chemistry and Biochemistry, University of Maryland, College ParkMaryland 20742USA[email protected]Search for other works by this author on:Lai-Xi WangLai-Xi WangDepartment of Chemistry and Biochemistry, University of Maryland, College ParkMaryland 20742USA[email protected]Search for other works by this author on:
-
CHAPTER 3: Chemical Biology of Protein O-Glycosylationp48-93ByPatrick K. Chaffey;Patrick K. ChaffeyDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of ColoradoBoulderCO 80303USA[email protected]Search for other works by this author on:Lianli Chi;Lianli ChiNational Glycoengineering Research Center and the State Key Laboratory of Microbial Technology, Shandong UniversityJinanShandong 250100ChinaSearch for other works by this author on:Zhongping TanZhongping TanDepartment of Chemistry and Biochemistry and BioFrontiers Institute, University of ColoradoBoulderCO 80303USA[email protected]Search for other works by this author on:
-
CHAPTER 4: Chemical Biology of O-GlcNAc Glycosylationp94-149ByNathan J. Cox;Nathan J. CoxDepartment of Biochemistry, Duke University School of MedicineDurhamNC 27710USAPharmacological Sciences Training Program, Duke University School of MedicineDurhamNC 27710USA[email protected]Search for other works by this author on:Thomas R. Meister;Thomas R. MeisterDepartment of Biochemistry, Duke University School of MedicineDurhamNC 27710USASearch for other works by this author on:Michael BoyceMichael BoyceDepartment of Biochemistry, Duke University School of MedicineDurhamNC 27710USAPharmacological Sciences Training Program, Duke University School of MedicineDurhamNC 27710USA[email protected]Search for other works by this author on:
-
CHAPTER 5: Chemical Synthesis and Engineering of N-Linked Glycoproteinsp150-187ByHongxing Li;Hongxing LiPeking University, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs38 Xueyuan RoadHaidian District, Beijing100191PR China[email protected]Search for other works by this author on:Yuankun Dao;Yuankun DaoPeking University, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs38 Xueyuan RoadHaidian District, Beijing100191PR China[email protected]Search for other works by this author on:Suwei DongSuwei DongPeking University, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs38 Xueyuan RoadHaidian District, Beijing100191PR China[email protected]Search for other works by this author on:
-
CHAPTER 6: Chemoenzymatic Synthesis of N-Glycansp188-208ByXuefeng Cao;Xuefeng CaoDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:Jun Zhou;Jun ZhouDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:Yuxi Guo;Yuxi GuoDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:Yunpeng Liu;Yunpeng LiuDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:Lei Li;Lei LiDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:Peng George WangPeng George WangDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University50 Decatur St SEAtlantaGA 30303USA[email protected]Search for other works by this author on:
-
CHAPTER 7: Towards Synthesis of Heparan Sulfate Glycopeptides and Proteoglycansp209-232BySherif Ramadan;Sherif RamadanDepartment of Chemistry, Michigan State University578 S. Shaw LaneEast LansingMichigan48824-1322USA[email protected]Chemistry Department, Faculty of Science, Benha UniversityBenhaQaliobiyaEgyptSearch for other works by this author on:Weizhun Yang;Weizhun YangDepartment of Chemistry, Michigan State University578 S. Shaw LaneEast LansingMichigan48824-1322USA[email protected]Search for other works by this author on:Xuefei HuangXuefei HuangDepartment of Chemistry, Michigan State University578 S. Shaw LaneEast LansingMichigan48824-1322USA[email protected]Search for other works by this author on:
-
CHAPTER 8: Chemoenzymatic Synthesis of Low-Molecular-Weight Heparin and Heparan Sulfatep233-252ByXing Zhang;Xing ZhangDepartment of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, and Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic InstituteTroy, New York 12180USA[email protected]Search for other works by this author on:Robert J. LinhardtRobert J. LinhardtDepartment of Chemistry and Chemical Biology, Department of Chemical and Biological Engineering, Department of Biology, and Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic InstituteTroy, New York 12180USA[email protected]Search for other works by this author on:
-
CHAPTER 9: Synthetic Studies of GPI-Anchored Peptides, Glycopeptides, and Proteinsp253-281ByJian Gao;Jian GaoNational Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University27 Shanda Nan LuJinan 250100ChinaSearch for other works by this author on:Zhongwu GuoZhongwu GuoDepartment of Chemistry, University of Florida214 Leigh HallP.O. Box 117200GainesvilleFL 32611USA[email protected]Search for other works by this author on:
-
CHAPTER 10: Chemical Approaches to Image Protein Glycosylationp282-299ByWei Lin;Wei LinCollege of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking UniversityBeijing 100871China[email protected]Search for other works by this author on:Ling Gao;Ling GaoCollege of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking UniversityBeijing 100871China[email protected]Search for other works by this author on:Ke Qin;Ke QinCollege of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking UniversityBeijing 100871China[email protected]Search for other works by this author on:Xing ChenXing ChenCollege of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking UniversityBeijing 100871China[email protected]Search for other works by this author on:
-
CHAPTER 11: Targeting Glycans of HIV Envelope Glycoproteins for Vaccine Designp300-357ByAnna-Janina Behrens;Anna-Janina BehrensOxford Glycobiology Institute, Department of Biochemistry, University of OxfordSouth Parks RoadOxford OX1 3QUUK[email protected]Search for other works by this author on:Gemma E. Seabright;Gemma E. SeabrightOxford Glycobiology Institute, Department of Biochemistry, University of OxfordSouth Parks RoadOxford OX1 3QUUK[email protected]Search for other works by this author on:Max CrispinMax CrispinOxford Glycobiology Institute, Department of Biochemistry, University of OxfordSouth Parks RoadOxford OX1 3QUUK[email protected]Search for other works by this author on:
-
CHAPTER 12: Design, Synthesis and Evaluation of Mucin Glycopeptide Based Cancer Vaccinep358-393ByZhanyi Sun;Zhanyi SunKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University100084P.R. China[email protected]Search for other works by this author on:Puguang Chen;Puguang ChenKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University100084P.R. China[email protected]Search for other works by this author on:Yanfang Liu;Yanfang LiuKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University100084P.R. China[email protected]Search for other works by this author on:Yanmei LiYanmei LiKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University100084P.R. China[email protected]Search for other works by this author on:
-
CHAPTER 13: Selective Chemical Glycosylation of Therapeutic Proteinsp394-414ByQun ZhouQun ZhouProtein Engineering, Biologics Research, Sanofi49 New York AvenueFraminghamMassachusetts 01701USA[email protected][email protected]Search for other works by this author on:
Spotlight
Advertisement
Advertisement