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Chemical Biology
Chemical Biology of Glycoproteins
Edited by
Zhongping Tan;
Zhongping Tan
University of Colorado Boulder, USA
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Lai-Xi Wang
Lai-Xi Wang
University of Maryland, USA
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Hardback ISBN:
978-1-78262-333-5
PDF ISBN:
978-1-78262-382-3
EPUB ISBN:
978-1-78801-122-8
Special Collection:
2017 ebook collection
Series:
Chemical Biology
No. of Pages:
421
Published online:
20 Mar 2017
Published in print:
27 Mar 2017
Book Chapter
CHAPTER 12: Design, Synthesis and Evaluation of Mucin Glycopeptide Based Cancer Vaccine
By
Zhanyi Sun
;
Zhanyi Sun
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University
100084
P.R. China
[email protected]
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Puguang Chen
;
Puguang Chen
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University
100084
P.R. China
[email protected]
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Yanfang Liu
;
Yanfang Liu
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University
100084
P.R. China
[email protected]
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Yanmei Li
Yanmei Li
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University
100084
P.R. China
[email protected]
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Published:20 Mar 2017
-
Special Collection: 2017 ebook collectionSeries: Chemical Biology
Page range:
358 - 393
Citation
Z. Sun, P. Chen, Y. Liu, and Y. Li, in Chemical Biology of Glycoproteins, ed. Z. Tan and L. Wang, The Royal Society of Chemistry, 2017, pp. 358-393.
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Immunotherapy is one of the most effective techniques for the treatment of diseases. Anti-tumor vaccines have been widely researched. Mucin glycopeptides are considered to be one of the most promising antigens for anti-tumor vaccines. Mucin glycopeptides have weak immunogenicity and numerous immune-stimulating structures have been incorporated through chemical synthesis. In this chapter, we mainly focus on the mucin-based glycopeptide antitumor vaccines, including their design, synthesis and evaluation.
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