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As one of the unique carbon-based materials, graphene and its derivatives have unique optical, electrochemical, thermal and mechanical properties. Therefore, this material has been widely applied as a sensing material and component to be integrated into a sensing platform. In this chapter, we introduce the development and application of graphene-based materials and their application in food safety and quality control. Graphene-based sensing materials have outstanding performance for the determination of trace levels of target analytes in a complicated food matrix. In addition, graphene is readily integrated into an electrochemical sensing platform for food analysis.

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