The recent advances in sequencing technology, through the development of next-generation sequencing (NGS) platforms, have enabled the generation of genomes for a multitude of species. The volumes of data that can be generated by NGS technologies also allow for the generation of genome sequences for individuals within populations, rather than solely a single representative genome for the whole species. From these genomes, the generation of gene models, and the downstream protein sequence databases produced, underpin a vast array of biological and biomedical investigations, including most areas of the Life Sciences. As such, a critical step in genome biology is the...