Chapter 18: Imidazolidinones as Asymmetric Organocatalysts
Published:16 Nov 2015
P. G. Cozzi, A. Gualandi, L. Mengozzi, and C. M. Wilson, in Sustainable Catalysis: Without Metals or Other Endangered Elements, Part 2, ed. M. North and M. North, The Royal Society of Chemistry, 2015, ch. 18, pp. 164-195.
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Imidazolininone organocatalysts (MacMillan catalysts) are one of the most effective catalysts, used in many interesting organocatalytic reactions. Their robustness, easy preparation from amino acids, and widespread use, make them one of the most powerful catalysts for general enantioselective transformations. The imidazolidinone catalysts promote new reaction modes in organocatalysis, such as SOMO activation and enantioselective photocatalytic reactions. Herein, the key principles underpinning their functionality and their reported use are summarised.