Chapter 23: Chiral Guanidines as Asymmetric Organocatalysts
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Published:16 Nov 2015
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Special Collection: 2015 ebook collection , ECCC Environmental eBooks 1968-2022 , 2011-2015 physical chemistry subject collectionSeries: Green Chemistry
C. W. Kee and C. Tan, in Sustainable Catalysis: Without Metals or Other Endangered Elements, Part 2, ed. M. North and M. North, The Royal Society of Chemistry, 2015, ch. 23, pp. 381-405.
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The unique reactivity and selectivity of guanidine catalysts in a wide range of reactions renders them important tools in organic chemistry. Most of these reports are derived from academic research, with no consideration of the environmental impact of the choice of solvent, reagent or protecting groups. In this chapter, we attempt to discuss guanidine-catalysed asymmetric catalysis through the lens of green/sustainable chemistry. We have adopted a semiquantitative approach to highlight various issues that are relevant to sustainable catalysis. Consideration of waste generation (with simple green chemistry metrics) and solvents was used.
