Molecularly Imprinted Polymers for Analytical Chemistry Applications
CHAPTER 14: Molecularly Imprinted Polymer Sensor Arrays
Published:25 Apr 2018
Special Collection: 2018 ebook collectionSeries: Polymer Chemistry Series
P. Li, W. J. Richardson, D. Song, and K. D. Shimizu, in Molecularly Imprinted Polymers for Analytical Chemistry Applications, ed. W. Kutner and P. S. Sharma, The Royal Society of Chemistry, 2018, pp. 447-474.
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This chapter provides an updated review of research about chemosensor arrays and assays assembled from molecularly imprinted polymers (MIPs) and imprinted materials. The molecular imprinting process provides rapid and inexpensive access to tailorable molecular recognition elements for sensing applications. However, chemosensors based on individual MIPs typically reveal low selectivity and high cross-reactivity. Assembling multiple MIPs into an array presents a convenient and effective solution to this problem. The binding pattern of each analyte to an array of MIPs can provide a unique fingerprint which can be classified using multivariate pattern recognition algorithms. In this chapter, key aspects in designing and developing MIP sensor arrays will be discussed, including the choice of template and monomer, polymer matrix and morphology, signaling mechanisms, and statistical data analysis. Selected examples from the literature are presented to highlight unique advantages and applications of the MIP chemosensor array as well as future problems and challenges.