Chapter 8: Functional Metal-organic Frameworks for Enzyme/Protein Immobilization
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Published:05 May 2017
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Special Collection: 2017 ebook collection
W. Liu, S. Lirio, H. Huang, and S. Ma, in Functional Supramolecular Materials: From Surfaces to MOFs, ed. R. Banerjee, The Royal Society of Chemistry, 2017, ch. 8, pp. 281-296.
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In recent years, metal-organic frameworks (MOFs) have attracted more attention due to their unique properties such as high chemical and thermal stability, tunable pore size, ease of modification and high surface area. These features allow them to be promising candidates various applications. More recently, MOFs have been applied as support for enzyme immobilization. Enzymes (or protein) are natural products that are considered as green catalysts but their cost is higher than conventional organic catalysts. Immobilization of enzymes on various MOFs is a novel concept that provides enzyme stability, activity and even selectivity. In this chapter, we summarized the three main techniques for enzyme immobilization in which the mechanisms, interactions, advantages and disadvantages are discussed.