Biophysics and Biochemistry of Cartilage by NMR and MRI
CHAPTER 12: Low-Field and Field-Cycling NMR and MRI of Cartilage
Published:09 Nov 2016
Special Collection: 2016 ebook collectionSeries: New Developments in NMR
S. Stapf, C. Mattea, and E. Rössler, in Biophysics and Biochemistry of Cartilage by NMR and MRI, ed. Y. Xia and K. Momot, The Royal Society of Chemistry, 2016, pp. 320-346.
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Low-field experiments possess the double advantage of providing stronger relaxation contrast and feasibility of studies with small-scale, mobile scanners. Ex vivo measurements deliver high-resolution profiles that are suitable for correlating experimental parameters with corresponding magnetic resonance imaging experiments of lower spatial resolution. In addition, determining the field-dependence of relaxation times represents a unique approach to relate slow molecular dynamics with the mobility and concentration of proteins in cartilage tissue, making use of the interaction of protons with the ubiquitous, quadrupolar nitrogen nuclei. This chapter presents the state-of-the-art of nuclear magnetic resonance studies with mobile scanners and field-cycling instruments.