Photodynamic Medicine: From Bench to Clinic
Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of diseases. This book reviews the current state of development of PDT, and also presents the foreseeable advancements of the field in the next decade. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find this book an invaluable source of information.
Chapters are drawn from research discussed at the 10th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice in Brixen and are written and edited by leaders in the field. Mirroring the philosophy of that meeting, this book contains an informative balance of the basic science and clinical applications of PDT. Following an introduction to PDT, its history, and how techniques have developed, chapters serve as a practical guide for practitioners, covering topics such as sensitizer dosage and light dosage, and examples of relevant studies. The text goes further to explore areas outside the medical field, such as the impact of PDT on society and the environment, and the economics of therapies.
This book is dedicated to the memory of Professor Giulio Jori, an expert in this field, who sadly passed away on the 23rd December 2014.
Photodynamic Medicine: From Bench to Clinic, The Royal Society of Chemistry, 2016.
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Table of contents
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CHAPTER 1: The Journey of PDT Throughout History: PDT from Pharos to Presentp1-21ByMahmoud H. Abdel-kaderMahmoud H. Abdel-kaderGerman UniversityCairo, EgyptSearch for other works by this author on:
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CHAPTER 2: Photosensitisers for Photodynamic Therapy: State of the Art and Perspectivesp23-62ByBeatriz Rodríguez-Amigo;Beatriz Rodríguez-AmigoInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:Oriol Planas;Oriol PlanasInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:Roger Bresolí-Obach;Roger Bresolí-ObachInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:Joaquim Torra;Joaquim TorraInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:Rubén Ruiz-González;Rubén Ruiz-GonzálezInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:Santi NonellSanti NonellInstitut Químic de Sarrià, Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain[email protected]Search for other works by this author on:
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CHAPTER 3: Basic Biological Mechanisms of Photodynamic Diagnosis/Photodynamic Therapyp63-74ByB. Krammer;B. KrammerDepartment of Molecular Biology, University of SalzburgHellbrunnerstr. 345020 SalzburgAustria[email protected]Search for other works by this author on:T. VerwangerT. VerwangerDepartment of Molecular Biology, University of SalzburgHellbrunnerstr. 345020 SalzburgAustria[email protected]Search for other works by this author on:
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CHAPTER 4: The Story of ALA Photodynamic Therapy: A Cancer Enigmap75-86ByAbraham NudelmanAbraham NudelmanThe Marcus Center for Medicinal Chemistry at the Chemistry Department Bar-Ilan UniversityRamat-Gan 5290002IsraelSearch for other works by this author on:
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CHAPTER 5: The Tumor Microenvironment Modulates Responsiveness to Photodynamic Therapyp87-99ByCharles J. Gomer;Charles J. GomerDepartment of Pediatrics, Keck School of Medicine, University of Southern CaliforniaLos AngelesCAUSASearch for other works by this author on:Sam WongSam WongSearch for other works by this author on:
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CHAPTER 6: Multifunctional Nanoparticles for Theranostic or X-Ray-Induced Photodynamic Therapyp101-112ByC. Frochot;C. FrochotLRGP, CNRS UMR 7274, Université de Lorraine, ENSIC1 Rue Grandville54000 NancyFrance[email protected]Search for other works by this author on:M. Barberi-HeyobM. Barberi-HeyobCRAN, CNRS UMR 7039, Université de LorraineCampus Sciences BP 70239 - 54506 Vandoeuvre CedexFranceSearch for other works by this author on:
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CHAPTER 7: Metallic Nanoparticles for Targeted Delivery of Photosensitisers for Photodynamic Therapyp113-135ByPaula García Calavia;Paula García CalaviaSchool, of Chemistry, University of East Anglia, Norwich Research ParkNorwichNR4 7TJUK[email protected]Search for other works by this author on:David A. RussellDavid A. RussellSchool, of Chemistry, University of East Anglia, Norwich Research ParkNorwichNR4 7TJUK[email protected]Search for other works by this author on:
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CHAPTER 8: Targeted Photodynamic Therapy—An Assimilation of Successes, Challenges and Future Directionsp137-160ByGirgis Obaid;Girgis ObaidWellman Center for Photomedicine, Harvard Medical School, Massachusetts General HospitalBostonMA 02114USA[email protected]Search for other works by this author on:Huang-Chiao Huang;Huang-Chiao HuangWellman Center for Photomedicine, Harvard Medical School, Massachusetts General HospitalBostonMA 02114USA[email protected]Search for other works by this author on:Tayyaba HasanTayyaba HasanWellman Center for Photomedicine, Harvard Medical School, Massachusetts General HospitalBostonMA 02114USA[email protected]Search for other works by this author on:
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CHAPTER 9: Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectivesp161-180ByAnette Weyergang;Anette WeyergangDepartment of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University HospitalNorway[email protected]Search for other works by this author on:Kristian Berg;Kristian BergDepartment of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University HospitalNorway[email protected]Search for other works by this author on:Pål K. SelboPål K. SelboDepartment of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University HospitalNorway[email protected]Cancer Stem Cell Innovation Center (SFI-CAST), Institute for Cancer Research, Norwegian Radium Hospital, Oslo University HospitalNorway[email protected]Search for other works by this author on:
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CHAPTER 10: Photochemical Internalization – A Technology for Intracellular Drug Delivery: The Bleomycin Casep181-196ByKristian BergKristian BergDept. of Radiation Biology, The Norwegian Radium HospitalMontebelloN-0310 Norway[email protected]http://www.ous-research.no/berg/Search for other works by this author on:
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CHAPTER 11: Mind the Gap: 3D Models in Photodynamic Therapyp197-221ByImran Rizvi;Imran RizviWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolBostonMA 02114USADepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolCambridgeMA 02139USA[email protected]Search for other works by this author on:Anne-Laure Bulin;Anne-Laure BulinWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolBostonMA 02114USASearch for other works by this author on:Emma Briars;Emma BriarsWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolBostonMA 02114USASearch for other works by this author on:Sriram Anbil;Sriram AnbilWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolBostonMA 02114USAHoward Hughes Medical InstituteChevy ChaseMD 20815USASearch for other works by this author on:Tayyaba HasanTayyaba HasanWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolBostonMA 02114USASearch for other works by this author on:
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CHAPTER 12: Instrumentation for Clinical Photodynamic Therapy and Photodynamic Diagnosisp223-243ByB. C. WilsonB. C. WilsonPrincess Margaret Cancer Centre/University Health Network and University of TorontoTMDT 15-314, 101 College St.TorontoON M5G 1L7Canada[email protected]Search for other works by this author on:
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CHAPTER 13: Optical Guidance for Therapeutic Interventionsp245-258ByB. C. Wilson;B. C. WilsonPrincess Margaret Cancer Centre/University of TorontoTMDT 15-314, 101 College St.TorontoON M5G 1L7Canada[email protected]Search for other works by this author on:R. WeersinkR. WeersinkPrincess Margaret Cancer Centre/University of TorontoTMDT 15-314, 101 College St.TorontoON M5G 1L7Canada[email protected]Search for other works by this author on:
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CHAPTER 14: Photodynamic Therapy Within the Global Treatment of Thoracic Cancersp259-278ByKeyvan MoghissiKeyvan MoghissiThe Yorkshire Laser Centre, Goole & District HospitalWoodland Avenue, GooleEast YorkshireDN14 6RXUK[email protected]Search for other works by this author on:
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CHAPTER 15: Methyl-Aminolevulinate/Aminolevulinic Acid Photodynamic Therapy: State of the Art in Dermatology and Possible Developmentsp279-288ByPiergiacomo Calzavara-PintonPiergiacomo Calzavara-PintonDermatology Department, University of Brescia, Spedali Civili HospitalPiazzale Spedali Civili 125123 BresciaItaly[email protected]Search for other works by this author on:
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CHAPTER 16: Photodynamic Therapy and Schizophreniap289-298ByAlexis SidoroffAlexis SidoroffDepartment of Dermatology and Venereology, Medical University of InnsbruckA-6020 InnsbruckAustriaSearch for other works by this author on:
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CHAPTER 17: Photodynamic Therapy in Aesthetic Dermatologyp299-308ByTheresa Hommel;Theresa HommelKlinikum VEST GmbH, Behandlungszentrum Knappschaftskrankenhaus Recklinghausen, Klinik für Dermatologie und AllergologieDorstener Strasse 151D-45657 RecklinghausenGermany[email protected]Search for other works by this author on:Rolf-Markus SzeimiesRolf-Markus SzeimiesKlinikum VEST GmbH, Behandlungszentrum Knappschaftskrankenhaus Recklinghausen, Klinik für Dermatologie und AllergologieDorstener Strasse 151D-45657 RecklinghausenGermany[email protected]Search for other works by this author on:
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CHAPTER 18: Perspectives of Non-Methyl-Aminolevulinate/Aminolevulinic Acid Photodynamic Therapy in Dermatologyp309-320ByBernhard OrtelBernhard OrtelDivision of Dermatology, NorthShore University HealthSystem9933 Woods DriveSkokieIL 60077USA[email protected]Search for other works by this author on:
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CHAPTER 19: Pre-Clinical Models for Glioma Photodynamic Therapyp321-351ByCarl Fisher;Carl FisherDepartment of Medical Biophysics, University of Toronto101 College St, Rm. 15-301TorontoONCanadaSearch for other works by this author on:Warren Foltz;Warren FoltzDepartment of Radiation Oncology, University Health Network101 College St, Rm. 7-301TorontoONCanadaSearch for other works by this author on:Lothar LilgeLothar LilgeDepartment of Medical Biophysics, University of Toronto101 College St, Rm. 15-301TorontoONCanadaPrincess Margaret Cancer Centre, University Healy Network101 College St, Rm. 15-310TorontoONCanada[email protected]Search for other works by this author on:
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CHAPTER 20: Photodynamic Medicine in Neurosurgery: Biochemical, Technical and Clinical Aspectsp353-403ByHerwig Kostron;Herwig KostronPrivate, Hospital Hochrum and Medical University of InnsbruckKaiser Franz Josefstrasse 10A6020 Austria[email protected]Search for other works by this author on:Sadao Kaneko;Sadao KanekoKashiwaba Neurosurgical Hospital7–20, 15-tyoume, 1-jyou, Tsukisamu- Higashi, Toyohira-kuSapporoHokkaido062-5813 Japan[email protected]Search for other works by this author on:Herbert Stepp;Herbert SteppLaser-Forschungslabor, LIFE Center, University Hospital of MunichFeodor-Lynen-Str. 1981377 MunichGermany[email protected]Search for other works by this author on:Sam EljamelSam EljamelSearch for other works by this author on:
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CHAPTER 21: Present Status of Photodynamic Therapy for Lung Cancer in Japanp405-420ByK. Furukawa;K. FurukawaTokyo Medical University, Department of Thoracic SurgeryShinjuku-kuTokyo160-0023Japan[email protected]Tokyo Medical University Ibaraki Medical Center, Department of Thoracic SurgeryInashiki-gunIbaraki300-0395JapanSearch for other works by this author on:Y. Kato;Y. KatoTokyo Medical University, Department of Thoracic SurgeryShinjuku-kuTokyo160-0023Japan[email protected]Tokyo Medical University Ibaraki Medical Center, Department of Thoracic SurgeryInashiki-gunIbaraki300-0395JapanSearch for other works by this author on:J. Usuda;J. UsudaNippon Medical School, Graduate School of Medicine, Department of Thoracic SurgeryBunkyou-kuTokyo113-0022JapanSearch for other works by this author on:H. KatoH. KatoTokyo Medical University, Department of Thoracic SurgeryShinjuku-kuTokyo160-0023Japan[email protected]Niizashiki General Hospital, Department of Thoracic SurgeryNiiza CitySaitama352-0001JapanSannou Hospital, International University of Health and Welfare, Department of Pulmonary Disease CenterMinato-kuTokyo 107-0062JapanSearch for other works by this author on:
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CHAPTER 22: Contrast-Enhanced Imaging of Photodynamic Therapy in Pancreatic Cancer: From Mouse to Manp421-439ByKimberley S. Samkoe;Kimberley S. SamkoeDepartment of Surgery, Geisel School of Medicine, Dartmouth College1 Rope Ferry RoadHanoverNH 03755USA[email protected]Thayer School of Engineering, Dartmouth College14 Engineering DriveHanoverNH 03755USASearch for other works by this author on:Scott C. Davis;Scott C. DavisThayer School of Engineering, Dartmouth College14 Engineering DriveHanoverNH 03755USASearch for other works by this author on:Brian W. PogueBrian W. PogueDepartment of Surgery, Geisel School of Medicine, Dartmouth College1 Rope Ferry RoadHanoverNH 03755USA[email protected]Thayer School of Engineering, Dartmouth College14 Engineering DriveHanoverNH 03755USASearch for other works by this author on:
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CHAPTER 23: Photodynamic Therapy in Gastroenterologyp441-447ByV. Maunoury;V. MaunouryGastroenterology Department, Lille University HospitalF-59000 LilleFranceSearch for other works by this author on:S. MordonS. MordonUniv. Lille, Inserm, CHU Lille, U1189 – ONCO-THAI – Image Assisted Laser Therapy for Oncology, Lille University HospitalF-59000 Lille59037 LILLE CedexFrance[email protected]Search for other works by this author on:
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CHAPTER 24: Head and Neck Photodynamic Therapyp449-460ByColin HopperColin HopperSearch for other works by this author on:
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CHAPTER 25: Vascular-Targeted Photodynamic Therapy in Prostate Cancer: From Bench to Clinicp461-480ByAvigdor Scherz;Avigdor ScherzDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceRehovotIsrael[email protected]Search for other works by this author on:Yoram Salomon;Yoram SalomonDepartment of Biological Regulation, Weizmann Institute of ScienceRehovotIsraelSearch for other works by this author on:Uri Lindner;Uri LindnerDepartment of Urology, Kaplan Medical CenterRehovotIsraelSearch for other works by this author on:Jonathan ColemanJonathan ColemanDepartment of Surgery, Urology Service, Memorial Sloan Kettering Cancer CenterNew YorkNYUSASearch for other works by this author on:
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CHAPTER 26: Photodynamic Therapy in Gynaecology: The Long Way from Bench to Bedside—Photodynamic Therapy for Cervical Dysplasiap481-502ByPeter HillemannsPeter HillemannsSearch for other works by this author on:
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CHAPTER 27: The New Possibilities of Autofluorescence Diagnosis in Clinical Practicep503-518BySieroń Aleksander;Sieroń AleksanderSchool of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and TherapyBatorego 15, 41-902BytomPoland[email protected]Search for other works by this author on:Kawczyk-Krupka Aleksandra;Kawczyk-Krupka AleksandraSchool of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and TherapyBatorego 15, 41-902BytomPoland[email protected]Search for other works by this author on:Kwiatek SebastianKwiatek SebastianSchool of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and TherapyBatorego 15, 41-902BytomPoland[email protected]Search for other works by this author on:
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CHAPTER 28: Antimicrobial Photodynamic Therapy: A Decade of Development and Clinical Studyp519-548ByC. CrossC. CrossSearch for other works by this author on:
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CHAPTER 29: Antimicrobial Photodynamic Therapy: New Anti-Infectives in the Age of Resistancep549-571ByMichael R. HamblinMichael R. HamblinDepartment of Dermatology, Harvard Medical SchoolBostonMA 02115USAHarvard-MIT Division of Health Sciences and TechnologyCambridgeMA 02139USASearch for other works by this author on:
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CHAPTER 30: Photodynamic Therapy for Vector-Borne Diseases1p573-590ByO. CoppellottiO. CoppellottiSearch for other works by this author on:
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CHAPTER 31: Photodynamic Reactions As a Marker of Cerebral Vascular Diseasesp591-599ByR. Bourcier;R. BourcierRadiology, HGRL44093 NantesFranceSearch for other works by this author on:N. Nighoghossian;N. NighoghossianHospices Civils de Lyon69000 LyonFranceSearch for other works by this author on:T. Ritzenthaler;T. RitzenthalerHospices Civils de Lyon69000 LyonFranceSearch for other works by this author on:B. Claustrat;B. ClaustratHospices Civils de Lyon69000 LyonFranceSearch for other works by this author on:T. PatriceT. PatriceSearch for other works by this author on:
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CHAPTER 32: Photodynamic Therapy in Clinical Cancer Carep601-622ByStephen G. BownStephen G. BownResearch Department of Tissue and Energy, Division of Surgery and Interventional Science, University College LondonWing 2.4 Cruciform Building, Gower StLondon WC1E 6BTUK[email protected]Search for other works by this author on:
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CHAPTER 33: Summary and Perspectivesp623-632ByTayyaba HasanTayyaba HasanWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital40 Blossom Street, (Bartlett 314)BostonMA 02114USA[email protected]Search for other works by this author on:
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