Biocatalysis: An Industrial Perspective
CHAPTER 13: EziG: A Universal Platform for Enzyme Immobilisation
Published:02 Nov 2017
Special Collection: 2017 ebook collectionSeries: Catalysis Series
Karim Engelmark Cassimjee, Hans-Jürgen Federsel, 2017. "EziG: A Universal Platform for Enzyme Immobilisation", Biocatalysis: An Industrial Perspective, Gonzalo de Gonzalo, Pablo Domínguez de María
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EnginZyme, a Swedish biocatalysis company founded in 2014, aims to reduce the environmental impact of the chemical industry by developing products that make it easier and more cost efficient to use enzymes. Currently, the company is addressing the issues of high enzyme cost and process implementation by marketing EziG™, a universal enzyme immobilisation material. EziG eliminates several common issues with enzyme immobilisation and is workable for all enzyme types. This designed enzyme carrier can be used for direct extraction of enzyme from crude preparations, and high loadings of active enzyme are achieved. As an alternative to costly immobilisation testing towards an uncertain end, assured biocatalyst reusability gives benefits beyond the direct economic gain of lower biocatalyst cost, including focus changes in enzyme engineering and simpler work-up procedures. EziG can be used as a standard heterogeneous catalyst, as well as in flow chemistry with packed bed reactors. The importance of this technology in growing the field remains to be evaluated. However, the issues that are now resolved have been identified as key barriers to increased industrial implementation. EziG may play an important role in the ongoing greening of the chemical production industry.