Skip Nav Destination
Theoretical and Computational Chemistry Series
Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis
Edited by
Vicent Moliner
Vicent Moliner
Universitat Jaume I, Spain
Search for other works by this author on:
Hardback ISBN:
978-1-78262-429-5
PDF ISBN:
978-1-78262-683-1
EPUB ISBN:
978-1-78262-967-2
Special Collection:
2016 ebook collection
No. of Pages:
535
Publication date:
16 Nov 2016
Book Chapter
Chapter 13: Effects of Water and Non-aqueous Solvents on Enzyme Activity
By
Eva Pluhařová
Ecole Normale Supérieure – PSL Research University, Chemistry Department, Sorbonne Universities – UPMC Univ Paris 06 CNRS UMR 8640 PASTEUR 24 rue Lhomond 75005 Paris France damien.laage@ens.fr
Eva Pluhařová
Search for other works by this author on:
Nicolas Chéron
Ecole Normale Supérieure – PSL Research University, Chemistry Department, Sorbonne Universities – UPMC Univ Paris 06 CNRS UMR 8640 PASTEUR 24 rue Lhomond 75005 Paris France damien.laage@ens.fr
Nicolas Chéron
Search for other works by this author on:
-
Published:16 Nov 2016
-
Special Collection: 2016 ebook collection
Citation
Eva Pluhařová, Nicolas Chéron, Damien Laage, 2016. "Effects of Water and Non-aqueous Solvents on Enzyme Activity", Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis, Inaki Tunon, Vicent Moliner
Download citation file:
In this chapter, we review the available experimental data and molecular models describing the effect of different solvents, including water, on the catalytic activity of enzymes. While a popular picture suggests that water acts as a lubricant of the protein conformational motions required for catalysis, we show that this dynamical picture is not supported by recent results and we discuss alternative models.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Digital access
$64.60
