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Theoretical and Computational Chemistry Series
Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis
Edited by
Vicent Moliner
Vicent Moliner
Universitat Jaume I, Spain
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Hardback ISBN:
978-1-78262-429-5
PDF ISBN:
978-1-78262-683-1
EPUB ISBN:
978-1-78262-967-2
Special Collection:
2016 ebook collection
No. of Pages:
535
Publication date:
16 Nov 2016
Book Chapter
Chapter 13: Effects of Water and Non-aqueous Solvents on Enzyme Activity
By
Eva Pluhařová
;
Eva Pluhařová
Ecole Normale Supérieure – PSL Research University, Chemistry Department, Sorbonne Universities – UPMC Univ Paris 06
CNRS UMR 8640 PASTEUR
24 rue Lhomond
75005 Paris
France
damien.laage@ens.fr
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Nicolas Chéron
;
Nicolas Chéron
Ecole Normale Supérieure – PSL Research University, Chemistry Department, Sorbonne Universities – UPMC Univ Paris 06
CNRS UMR 8640 PASTEUR
24 rue Lhomond
75005 Paris
France
damien.laage@ens.fr
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Published:16 Nov 2016
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Special Collection: 2016 ebook collection
Citation
Eva Pluhařová, Nicolas Chéron, Damien Laage, 2016. "Effects of Water and Non-aqueous Solvents on Enzyme Activity", Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis, Inaki Tunon, Vicent Moliner
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In this chapter, we review the available experimental data and molecular models describing the effect of different solvents, including water, on the catalytic activity of enzymes. While a popular picture suggests that water acts as a lubricant of the protein conformational motions required for catalysis, we show that this dynamical picture is not supported by recent results and we discuss alternative models.
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