Most protein functions rely on their ability to deform or change shape in a precise and regulated way.^1–3  Protein flexibility is encoded in the structure that in turn is imprinted in the sequence.^2,4  Therefore, in addition to the average structure, evolution used protein dynamics to optimise function, from mechanical work, to transport or enzymatic activity.^2,4–8  The range and types of enzymatic motions is very broad: from local side-changes fluctuations to dramatic domain translocations including local folding/unfolding events.⁹  Such motions are critical to enzyme catalysis particularly to ligand binding/release and formation of the reactive cavity.^3,10  Thus,...