Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis
Chapter 15: Enzyme Design
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Published:16 Nov 2016
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Special Collection: 2016 ebook collection
Lur Alonso-Cotchico, Jaime Rodríguez-Guerra, Agustí Lledós, Jean-Didier Maréchal, 2016. "Enzyme Design", Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis, Inaki Tunon, Vicent Moliner
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Enzymes are one of the cornerstones of living organisms. They are catalysts that provide the catabolic and metabolic needs of the cells and the number of physiological processes they are involved in is legion. From their primary sequence to their expression, enzymes are one of the most important markers of evolution as they are modulated according to the necessities of cells. Amongst the examples that crystallise the importance of enzymes for living organisms is their involvement in frontline mechanisms of cellular defence. Cells would not be able to promptly respond to harmful stimuli generated by their surrounding (i.e. the absorption of pathogenic molecules) without a battery of efficient enzymes.1