Chapter 14: Artificial Biocatalytic Cascades to Alcohols and Amines
Published:31 May 2018
J. H. Schrittwieser, S. Velikogne, and W. Kroutil, in Modern Biocatalysis: Advances Towards Synthetic Biological Systems, ed. G. Williams and M. Hall, The Royal Society of Chemistry, 2018, ch. 14, pp. 387-438.
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Cascades have the advantage of circumventing the isolation of reaction intermediates, saving resources, reagents and time. Consequently, the cascade approach allows for increasing the efficiency of organic synthesis by omitting operational work-up steps, thereby reducing the ecological footprint and ideally increasing the yield of the overall transformation compared to a classical sequence of single-step transformations. The present book chapter focuses on biocatalytic linear cascades of the last five years, leading to products such as alcohols and amines.