Over the years, scientific methods continue to develop and advance in their complexity. In the last two decades, partly due to increases in computing power, many novel, multiplexed or data rich technologies have arrived on the market. These technologies are applicable to all aspects of the biological sciences and in general terms have given scientists the ability to study numerous biological or chemical variables simultaneously. In the field of toxicology this includes the discovery of (i) how compounds interact with organisms, (ii) how compounds interact with each other, (iii) increased sensitivity of methodologies, and (iv) the interplay of the previous three points. As the number of experimental variables increases so does the necessary computing power and mathematical algorithms needed for data interpretation. For some technologies their development can often outstrip the data analysis tools needed to determine biological or chemical meaning from the data. This chapter considers the current impact of these technologies in the field of chemical warfare agent (CWA) toxicology, highlighting successes and suggesting avenues for future research. The majority of information available is currently in the area of transcriptomics and proteomics (see Table 7.1). As such, this chapter will focus on these technologies, whilst also suggesting areas where researchers could improve the knowledge gained from these data rich technologies.